ArticleThe American journal of pathology1988
Cytophilic and cytotoxic properties of human eosinophil peroxidase plus major basic protein.
Article in The American journal of pathology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 22 citations in OpenAlex.
- Phase I imaging study of Hodgkin's disease and non-Hodgkin's lymphomas with radiolabeled antibody to eosinophil peroxidase.Cell biophysicsTrial
- Role of Macrophages in the Repair Process during the Tissue Migrating and Resident Helminth Infections.BioMed research international · 2016Review
- Degranulating eosinophils in human endometriosis.The American journal of pathology · 2000Article
- Superoxide production by human eosinophils can be inhibited in an agonist-selective manner.Agents and actions · 1992Article
- Immunopathological study of eosinophils in eosinophilic granuloma of bone: evidence for release of three cationic proteins and subsequent uptake in macrophages.Virchows Archiv. A, Pathological anatomy and histopathology · 1992Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The cytophilic and cytotoxic properties of an acetate-buffered solution of human eosinophil peroxidase (EPO) plus major basic protein (MBP) were studied to determine the cytotoxic potential of localized eosinophil degranulation in human tissues. When incubated with EPO + MBP for 5 minutes, viable cells of six unrelated types (Sp 2/0; HeLa; human gastric adenocarcinoma; acute lymphocytic leukemia; IM-9; benign lymphoid hyperplasia) developed varying degrees of cytochemically detectable deposits of EPO on the cell membranes. A single-step propidium iodide exclusion assay was then used to show that EPO + MBP in the absence of hydrogen peroxide is substantially cytotoxic only to the acute lymphocytic leukemia and IM-9 cells. In the presence of 0.003% hydrogen peroxide, EPO + MBP was cytotoxic to five types of cells. It is concluded that human EPO in the presence of MBP has an affinity for the membrane of diverse cell types. The toxicity of EPO + MBP is markedly enhanced by the presence of hydrogen peroxide.
Indexed as
Identifiers
3414778PMC1880747W140740675What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.