Evidence map›Paper›PMID 34147716›Full record

ArticleBiomaterials2021

Optimized design of a hyperflexible sieve electrode to enhance neurovascular regeneration for a peripheral neural interface.

Austin Veith, Xue Li, Hailey Modi, Ali Abbaspour, Lan Luan, Chong Xie, Aaron B Baker

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Austin VeithThe University of Texas at Austin, Department of Biomedical Engineering, Austin, TX, USA.
Xue LiRice University, Department of Electrical and Computer Engineering, Houston, TX, USA.
Hailey ModiThe University of Texas at Austin, Department of Biomedical Engineering, Austin, TX, USA.
Ali AbbaspourThe University of Texas at Austin, Department of Biomedical Engineering, Austin, TX, USA.
Lan LuanRice University, Department of Electrical and Computer Engineering, Houston, TX, USA.
Chong XieRice University, Department of Electrical and Computer Engineering, Houston, TX, USA.
Aaron B BakerThe University of Texas at Austin, Department of Biomedical Engineering, Austin, TX, USA; Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX, USA; Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, TX, USA; Institute for Biomaterials, Drug Delivery and Regenerative Medicine, The University of Texas at Austin, Austin, TX, USA. Electronic address: abbaker1@gmail.com.

Funding

Engineering Effective Revascularization Strategies for Ischemia in Disease StatesDP2OD008716 · OD · UNIVERSITY OF TEXAS AT AUSTIN · PI BAKER, AARON BLAIR · 2011 to 2011
$2.3M
Mechanical Conditioning of Mesenchymal Stem Cells for Enhanced Recellularized Vascular GraftsR01HL141761 · NHLBI · UNIVERSITY OF TEXAS AT AUSTIN · PI BAKER, AARON BLAIR · 2018 to 2021
$1.6M
Syndecan-1 in Mechanosensing of Engineered MicroenvironmentsR21EB023551 · NIBIB · UNIVERSITY OF TEXAS AT AUSTIN · PI BAKER, AARON BLAIR · 2017 to 2018
$450k
Glycocalyx Mimetic Polysaccharides as Therapeutics for AtherosclerosisR21EB024147 · NIBIB · UNIVERSITY OF TEXAS AT AUSTIN · PI BAKER, AARON BLAIR · 2017 to 2018
$430k
NHLBI NIH HHS R01 HL141761NIBIB NIH HHS R21 EB023551NIBIB NIH HHS R21 EB024147NIH HHS DP2 OD008716
6 · The paper itself

Abstract

One in 190 Americans is currently living with the loss of a limb resulted from injury, amputation, or neurodegenerative disease. Advanced neuroprosthetic devices combine peripheral neural interfaces with sophisticated prosthetics and hold great potential for the rehabilitation of impaired motor and sensory functions. While robotic prosthetics have advanced very rapidly, peripheral neural interfaces have long been limited by the capability of interfacing with the peripheral nervous system. In this work, we developed a hyperflexible regenerative sieve electrode to serve as a peripheral neural interface. We examined tissue neurovascular integration through this novel device. We demonstrated that we could enhance the neurovascular invasion through the device with directional growth factor delivery. Furthermore, we demonstrated that we could reduce the tissue reaction to the device often seen in peripheral neural interfaces. Finally, we show that we can create a stable tissue device interface in a long-term implantation that does not impede the normal regenerative processes of the nerve. Our study developed an optimal platform for the continued development of hyperflexible sieve electrode peripheral neural interfaces.

Indexed as

Artificial LimbsNeurodegenerative DiseasesElectrodes, ImplantedHumansNerve RegenerationPeripheral NervesAngiogenesisHyperflexible electrodesNerve regenerationPeripheral neural interfaceRegenerative electrode

Identifiers

PMID34147716
PMCPMC9939235

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.