ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2022
Neural Response to Social Exclusion Moderates the Link Between Adolescent Anxiety Symptoms and Substance Use.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.
- The brain in social context: A systematic review of substance use and social processing from adolescence to young adulthood.Developmental cognitive neuroscience · 2022Pooled it
- Neural Underpinnings of Social Stress in Substance Use Disorders.Current topics in behavioral neurosciences · 2022Pooled it
- Anxiety symptoms interact with approach motivations in adolescent risk-taking.Development and psychopathology · 2026Article
- Identifying neural mediators and cultural moderators of the association between discrimination and depression among Mexican American youth.Scientific reports · 2025Article
- Attitudes of Adolescents Toward Addictive Substances: Hope and Self-Control as Protective Factors.Children (Basel, Switzerland) · 2025Article
- Neurodevelopmental Pathways from Temperamental Fear to Anxiety.Current topics in behavioral neurosciences · 2025Review
- Development of Comorbid Alcohol Use and Depressive Symptoms During Late Adolescence: Examining the Roles of Emotion Regulation and Gender Differences.Research on child and adolescent psychopathology · 2024Article
- Addressing stigma within the dissemination of research products to improve quality of care for pregnant and parenting people affected by substance use disorder.Frontiers in psychiatry · 2023Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSubstance use (SU) typically increases from middle to late adolescence. Anxiety is one factor associated with greater SU, although variability in who uses substances remains. Some models suggest that brain-based susceptibility markers could reveal which adolescents are at a higher risk for psychopathology, but it is unknown whether these individual differences attenuate or accentuate the association between anxiety and elevated SU even if normative. This study addressed this gap by testing whether neural response to social exclusion moderates the association between anxiety symptoms and increased SU from middle to late adolescence.
methodsParticipants were 181 Mexican-origin adolescents (48% female; 16-17 years old) who completed a social exclusion task during a functional magnetic resonance imaging scan and filled out questionnaires about their SU and anxiety symptoms. Analyses focused on neural response to social exclusion versus inclusion within 3 regions of interest and change in SU across 2 years.
resultsDorsal anterior cingulate cortex response to social exclusion, but not subgenual anterior cingulate cortex or anterior insula, moderated the relation between anxiety symptoms and SU, such that higher anxiety symptoms predicted a greater relative increase in SU only for those youth with a lower dorsal anterior cingulate cortex response to exclusion.
conclusionsBlunted dorsal anterior cingulate cortex response to social exclusion may serve as a neural susceptibility marker of altered conflict monitoring or emotion regulation in middle adolescence that, in combination with high levels of anxious feelings, elevates the risk for onset of and/or increased SU by late adolescence. These findings have implications for designing targeted interventions to mitigate SU among adolescents.
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