ArticleNeuroImage2021
Intra-session test-retest reliability of functional connectivity in infants.
Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Architectural reorganization of functional connectivity after propofol anesthesia exceeds within-state measurement variability and is only marginally reversed during early recovery.Neuroimage. Reports · 2026Article
- Excessive Censoring Degrades Individual-Specific Cortical Parcellations and Personalized TMS Targets.bioRxiv : the preprint server for biology · 2026Article
- Feature selection leads to divergent neurobiological interpretations of brain-based machine learning biomarkers.Nature human behaviour · 2026Article
- Perinatal hardship and infant neurodevelopment: insights from a global pandemic.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Overlooked features lead to divergent neurobiological interpretations of brain-based machine learning biomarkers.bioRxiv : the preprint server for biology · 2025Article
- Type-1 Diabetes Impacts Brain Microstructure and Anatomical Associations in Young and Well-Controlled Individuals.Brain topography · 2025Article
- The generalizability of cortical area parcellations across early childhood.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Exploring Graph Theory Mechanisms of Fluid Intelligence in the DLPFC: Insights From Resting-State fNIRS Across Various Time Windows.Brain and behavior · 2025Article
- TR(Acking) Individuals Down: Exploring the Effect of Temporal Resolution in Resting-State Functional MRI Fingerprinting.Human brain mapping · 2025Article
- How much is "enough"? Considerations for functional connectivity reliability in pediatric naturalistic fMRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Spatiotemporal dynamics of EEG microstate networks over the first two years of life: A multi-cohort longitudinal study.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Article
- Maternal childhood maltreatment: associations to offspring brain volume and white matter connectivity.Journal of developmental origins of health and disease · 2023Article
- Gestational age-related changes in the fetal functional connectome: in utero evidence for the global signal.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- The confound of head position in within-session connectome fingerprinting in infants.NeuroImage · 2023Article
- Resting-state functional connectivity identifies individuals and predicts age in 8-to-26-month-olds.Developmental cognitive neuroscience · 2022Article
- The effect of general anesthesia on the test-retest reliability of resting-state fMRI metrics and optimization of scan length.Frontiers in neuroscience · 2022Article
- The instability of functional connectomes across the first year of life.Developmental cognitive neuroscience · 2021Article
- A guide to the measurement and interpretation of fMRI test-retest reliability.Current opinion in behavioral sciences · 2021Article
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Authors and funding
22 authors at 6 institutions in 3 countries.
Funding
Abstract
Resting functional MRI studies of the infant brain are increasingly becoming an important tool in developmental neuroscience. Whereas the test-retest reliability of functional connectivity (FC) measures derived from resting fMRI data have been characterized in the adult and child brain, similar assessments have not been conducted in infants. In this study, we examined the intra-session test-retest reliability of FC measures from 119 infant brain MRI scans from four neurodevelopmental studies. We investigated edge-level and subject-level reliability within one MRI session (between and within runs) measured by the Intraclass correlation coefficient (ICC). First, using an atlas-based approach, we examined whole-brain connectivity as well as connectivity within two common resting fMRI networks - the default mode network (DMN) and the sensorimotor network (SMN). Second, we examined the influence of run duration, study site, and scanning manufacturer (e.g., Philips and General Electric) on ICCs. Lastly, we tested spatial similarity using the Jaccard Index from networks derived from independent component analysis (ICA). Consistent with resting fMRI studies from adults, our findings indicated poor edge-level reliability (ICC = 0.14-0.18), but moderate-to-good subject-level intra-session reliability for whole-brain, DMN, and SMN connectivity (ICC = 0.40-0.78). We also found significant effects of run duration, site, and scanning manufacturer on reliability estimates. Some ICA-derived networks showed strong spatial reproducibility (e.g., DMN, SMN, and Visual Network), and were labelled based on their spatial similarity to analogous networks measured in adults. These networks were reproducibly found across different study sites. However, other ICA-networks (e.g. Executive Control Network) did not show strong spatial reproducibility, suggesting that the reliability and/or maturational course of functional connectivity may vary by network. In sum, our findings suggest that developmental scientists may be on safe ground examining the functional organization of some major neural networks (e.g. DMN and SMN), but judicious interpretation of functional connectivity is essential to its ongoing success.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.