Evidence map›Paper›PMID 34147064›Full record

ArticleThe journal of headache and pain2021

Thalamo-cortical networks in subtypes of migraine with aura patients.

Gianluca Coppola, Antonio Di Renzo, Emanuele Tinelli, Barbara Petolicchio, Vincenzo Parisi, Mariano Serrao, Camillo Porcaro, Marco Fiorelli, Francesca Caramia, Jean Schoenen and 2 more

Abstract read
In one paragraph

Article in The journal of headache and pain, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Changes in the functional brain networks and graph theory analysis of patients with epilepsy and comorbid migraine without aura.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  4. Article
  5. Hallmarks of primary headache: part 1 - migraine.The journal of headache and pain · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Evaluating migraine with typical aura with neuroimaging.Frontiers in human neuroscience · 2023
    Review
  11. Article
  12. Article
  13. Article
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Gianluca CoppolaDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino, Corso della Repubblica 79, 04100, Latina, Italy. gianluca.coppola@uniroma1.it.
Antonio Di RenzoIRCCS - Fondazione Bietti, Rome, Italy.
Emanuele TinelliDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Barbara PetolicchioDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Vincenzo ParisiIRCCS - Fondazione Bietti, Rome, Italy.
Mariano SerraoDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino, Corso della Repubblica 79, 04100, Latina, Italy.
Camillo PorcaroInstitute of Cognitive Sciences and Technologies (ISTC) - National Research Council (CNR), Rome, Italy.
Marco FiorelliDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Francesca CaramiaDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Jean SchoenenHeadache Research Unit, University Department of Neurology CHR, Citadelle Hospital, University of Liège, Liège, Belgium.
Vittorio Di PieroDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Francesco PierelliDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino, Corso della Repubblica 79, 04100, Latina, Italy.

Funding

Fondazione Roma Fondazione RomaItalian Ministry of Health Italian Ministry of Health
6 · The paper itself

Abstract

backgroundWe searched for differences in resting-state functional connectivity (FC) between brain networks and its relationship with the microstructure of the thalamus between migraine with pure visual auras (MA), and migraine with complex neurological auras (MA+), i.e. with the addition of at least one of sensory or language symptom.

methods3T MRI data were obtained from 20 patients with MA and 15 with MA + and compared with those from 19 healthy controls (HCs). We collected resting state data among independent component networks. Diffusivity metrics of bilateral thalami were calculated and correlated with resting state ICs-Z-scores.

resultsAs compared to HCs, both patients with MA and MA + disclosed disrupted FC between the default mode network (DMN) and the right dorsal attention system (DAS). The MA + subgroup had lower microstructural metrics than both HCs and the MA subgroup, which correlated negatively with the strength of DMN connectivity. Although the microstructural metrics of MA patients did not differ from those of HCs, these patients lacked the correlation with the strength of DAS connectivity found in HCs.

conclusionsThe present findings suggest that, as far as MRI profiles are concerned, the two clinical phenotypes of migraine with aura have both common and distinct morpho-functional features of nodes in the thalamo-cortical network.

Indexed as

EpilepsyMigraine DisordersMigraine with AuraBrainBrain MappingHumansMagnetic Resonance Imagingauradiffusion tensor imagingmigrainenetworksresting statethalamus

Identifiers

PMID34147064
PMCPMC8214259

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.