ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2021
Post-mortem examination of Hospital Inpatient COVID-19 Deaths in Lusaka, Zambia - A Descriptive Whole-body Autopsy Series.
Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
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12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Findings and inferences from full autopsies, minimally invasive autopsies and biopsy studies in patients who died as a result of COVID19 - A systematic review.Forensic science, medicine, and pathology · 2022Pooled it
- Prevalence of Acute Pulmonary Embolism at Autopsy in Patients With COVID-19.The American journal of cardiology · 2022Pooled it
- Active pulmonary tuberculosis and coronavirus disease 2019: A systematic review and meta-analysis.PloS one · 2021Pooled it
- Exploring key challenges for healthcare providers and stakeholders in delivering adolescent sexual and reproductive health services and information during the COVID-19 pandemic in Malawi, Zambia and Zimbabwe: a qualitative study.BMC health services research · 2024Article
- Spatially resolved single-cell atlas unveils a distinct cellular signature of fatal lung COVID-19 in a Malawian population.Nature medicine · 2024Article
- Intersecting epidemics: COVID-19 and HIV in sub-Saharan Africa. A systematic review (2020-2022).Journal of public health in Africa · 2023Article
- COVID-19 and tuberculosis coinfection: An overview of case reports/case series and meta-analysis of prevalence studies.Heliyon · 2023Review
- Saddle pulmonary embolism in the setting of COVID-19 infection: A systematic review of case reports and case series.Open medicine (Warsaw, Poland) · 2023Review
- Emerging Viral Infections, Hypertension, and Cardiovascular Disease in Sub-Saharan Africa: A Narrative Review.Hypertension (Dallas, Tex. : 1979) · 2022Review
- Autopsy findings in COVID-19 infection-related death: a systematic review.Egyptian journal of forensic sciences · 2022Review
- Clinical characteristics and histopathology of COVID-19 related deaths in South African adults.PloS one · 2022Article
- COVID-19 and Sudden Unexpected Community Deaths in Lusaka, Zambia, Africa - A Medico-Legal Whole-Body Autopsy Case Series.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021Article
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Authors and funding
14 authors at 4 institutions in 2 countries.
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Abstract
backgroundSince information on the pathology of COVID-19 from sub-Saharan Africa (SSA) remains scarce, the objective of our study was to define the gross pathology and histological features of COVID-19. We report data from 29 whole-body autopsies of COVID-19 deaths occurring in hospitals in Lusaka, Zambia - the first large autopsy case series from Africa.
methodsWe performed a descriptive post-mortem examination study of inpatient COVID-19 related deaths at two hospitals in Lusaka, Zambia. Whole-body autopsies were conducted according to Standard Operating Procedures. Gross and histopathological examinations of all organs were performed. Patient demographics, history, co-morbidities, autopsy gross and microscopic findings, and cause(s) of death were recorded and analyzed using STATA version 14. Variables were grouped and presented as frequencies and percentages.
findingsAutopsies were performed on 29 decedents (mean age = 44 ± 15.8years; age range = 19-82; 17/29 [58.8%] males). 22/29 [75.9%] cases were <55 years of age. A spectrum of pathological manifestations of COVID-19 were seen in all organs. The commonest causes of death were pulmonary thromboembolism (13/29, 45%), Diffuse Alveolar Damage (9/29, 31%), and COVID-19 pneumonia (7/29, 25%). 22/29 (76%) had co-morbidities. Common co-morbidities included HIV (8/29, 28%), Hypertension (6/29, 20%) Tuberculosis (3/29, 10%), Diabetes (3/29, 10%).
conclusionsA spectrum of gross anatomical and histopathological findings are seen in COVID-19 deaths in hospitalized decedents. These appear broadly similar to those reported from China, Europe and USA. Differences include a younger age group, and co-morbidities of HIV and TB co-infection which require further investigation.
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