Evidence map›Paper›PMID 34146583›Full record

ArticleMicrovascular research2021

Morphological characterization of Etv2 vascular explants using fractal analysis and atomic force microscopy.

Robert P Adelson, Brisa Palikuqi, Zachary Weiss, Antonio Checco, Ryan Schreiner, Shahin Rafii, Sina Y Rabbany

Open access · greenAbstract readComparative StudyVideo-Audio Media
In one paragraph

Article in Microvascular research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Robert P AdelsonBioengineering Program, DeMatteis School of Engineering and Applied Science, Hofstra University, Hempstead, NY, USA.
Brisa PalikuqiDivision of Regenerative Medicine, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Zachary WeissBioengineering Program, DeMatteis School of Engineering and Applied Science, Hofstra University, Hempstead, NY, USA.
Antonio CheccoBioengineering Program, DeMatteis School of Engineering and Applied Science, Hofstra University, Hempstead, NY, USA.
Ryan SchreinerDepartment of Ophthalmology, Margaret Dyson Vision Research Institute, Weill Cornell Medicine, New York, NY, USA.
Shahin RafiiDivision of Regenerative Medicine, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Sina Y RabbanyBioengineering Program, DeMatteis School of Engineering and Applied Science, Hofstra University, Hempstead, NY, USA; Division of Regenerative Medicine, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA. Electronic address: sina.y.rabbany@hofstra.edu.
Hofstra University · USWeill Cornell Medicine · USCornell University · US

Funding

Adaptable tissue-specific endothelial cells for organ regenerationR35HL150809 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Shahin Rafii · 2020 to 2026
$7.1M
Endothelial cell transplantation for multi-organ repair to counter radiation injuryU01AI138329 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI KIEM, HANS-PETER, RAFII, SHAHIN · 2018 to 2022
$3.3M
Evaluation of Pluripotent Stem Cell-Derived Blood Cells in Nonhuman Primate ModelR01HL115128 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KIEM, HANS-PETER, RAFII, SHAHIN · 2013 to 2016
$3.3M
Niche signals in HSC genesisRC2DK114777 · NIDDK · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BERNSTEIN, IRWIN D, RAFII, SHAHIN · 2017 to 2021
$3.3M
Deciphering molecular determinants of vascular heterogeneity for organ repairR01HL128158 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI RAFII, SHAHIN · 2014 to 2018
$3.1M
Identification of vascular-derived signals for alveolar lung repairR01HL119872 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI RAFII, SHAHIN · 2013 to 2016
$2.3M
Identification of vascular inductive signals in liver regenerationR01DK095039 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI RAFII, SHAHIN · 2012 to 2016
$2.2M
Molecular Determinants of endothelial transition into engraftable hematopoietic cellsR01HL139056 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI RAFII, SHAHIN · 2018 to 2019
$1.4M
NHLBI NIH HHS R01 HL115128NHLBI NIH HHS R01 HL119872NHLBI NIH HHS R01 HL128158NHLBI NIH HHS R01 HL139056NHLBI NIH HHS R35 HL150809NIAID NIH HHS U01 AI138329NIDDK NIH HHS R01 DK095039NIDDK NIH HHS RC2 DK114777
6 · The paper itself

Abstract

The rapid engraftment of vascular networks is critical for functional incorporation of tissue explants. However, existing methods for inducing angiogenesis utilize approaches that yield vasculature with poor temporal stability or inadequate mechanical integrity, which reduce their robustness in vivo. The transcription factor Ets variant 2 (Etv2) specifies embryonic hematopoietic and vascular endothelial cell (EC) development, and is transiently reactivated during postnatal vascular regeneration and tumor angiogenesis. This study investigates the role for Etv2 upregulation in forming stable vascular beds both in vitro and in vivo. Control and Etv2

Indexed as

Cell ShapeFractalsImage Processing, Computer-AssistedMicroscopy, Atomic ForceNeovascularization, PhysiologicCells, CulturedCoculture TechniquesColonic NeoplasmsHumansHuman Umbilical Vein Endothelial CellsNeovascularization, PathologicProtocadherinsTissue Culture TechniquesTranscription FactorsVascular Endothelial Growth Factor Receptor-2ETV2 protein, humanKDR protein, humanPCDH12 protein, humanProtocadherinsTranscription FactorsVascular Endothelial Growth Factor Receptor-2Adipose-derived endothelial cellsAngiogenesisAtomic force microscopyEts variant 2F-actinFractal dimensionHUVECsLacunarityVascular engraftment

Identifiers

PMID34146583
PMCPMC8446305
OpenAlexW3167752489

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.