Evidence map›Paper›PMID 34146484›Full record

ArticleCurrent biology : CB2021

LC3B phosphorylation regulates FYCO1 binding and directional transport of autophagosomes.

Jose L Nieto-Torres, Sean-Luc Shanahan, Romain Chassefeyre, Tai Chaiamarit, Sviatlana Zaretski, Sara Landeras-Bueno, Adriaan Verhelle, Sandra E Encalada, Malene Hansen

Open access · bronzeAbstract read
In one paragraph

Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Exploiting autophagy and related pathways: pioneering new horizons in cataract therapy.Apoptosis : an international journal on programmed cell death · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. STRIPAK, a fundamental signaling hub of eukaryotic development.Microbiology and molecular biology reviews : MMBR · 2024
    Review
  10. Review
  11. Article
  12. Review
  13. The Third Annual Symposium of the Midwest Aging Consortium.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024
    Article
  14. Review
  15. Article
  16. Article
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  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jose L Nieto-TorresProgram of Development, Aging and Regeneration, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Sean-Luc ShanahanProgram of Development, Aging and Regeneration, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Romain ChassefeyreDepartment of Molecular Medicine, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA.
Tai ChaiamaritDepartment of Molecular Medicine, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA.
Sviatlana ZaretskiProgram of Development, Aging and Regeneration, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Sara Landeras-BuenoDepartment of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Adriaan VerhelleDepartment of Molecular Medicine, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA.
Sandra E EncaladaDepartment of Molecular Medicine, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: encalada@scripps.edu.
Malene HansenProgram of Development, Aging and Regeneration, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. Electronic address: mhansen@sbpdiscovery.org.
Scripps Research Institute · USSanford Burnham Prebys Medical Discovery Institute · USDiscovery Institute · US

Funding

Tumor Microenvironment and Cancer ImmunologyP30CA030199 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Jianhua Zhao · 1985 to 2026
$107.2M
Regulation of the Autophagy Process in Organismal AgingR01AG038664 · NIA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Malene Hansen · 2011 to 2026
$6.4M
Mechanisms of Toxicity in C. elegans Models of Transthyretin AmyloidosisR01AG049483 · NIA · SCRIPPS RESEARCH INSTITUTE, THE · PI ENCALADA, SANDRA E · 2016 to 2020
$2.4M
Autophagy Regulation by Hippo Kinases STK3/STK4R01GM117466 · NIGMS · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI HANSEN, MALENE · 2016 to 2019
$1.5M
Mechanisms of Aging: Regulation of Canonical and Non-canonical AutophagyK99AG062774 · NIA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI NIETO-TORRES, JOSE LUIS · 2019 to 2021
$396k
NCI NIH HHS P30 CA030199NIA NIH HHS K99 AG062774NIA NIH HHS R01 AG038664NIA NIH HHS R01 AG049483NIGMS NIH HHS R01 GM117466
6 · The paper itself

Abstract

Macroautophagy (hereafter referred to as autophagy) is a conserved process that promotes cellular homeostasis through the degradation of cytosolic components, also known as cargo. During autophagy, cargo is sequestered into double-membrane vesicles called autophagosomes, which are predominantly transported in the retrograde direction to the perinuclear region to fuse with lysosomes, thus ensuring cargo degradation.

Indexed as

AutophagosomesMicrotubule-Associated ProteinsProtein Processing, Post-TranslationalAnimalsAutophagyAutophagy-Related Protein 8 FamilyPhosphorylationAutophagy-Related Protein 8 FamilyMicrotubule-Associated ProteinsautophagyFYCO1Hippo kinasesLC3BstarvationSTK4traffickingvesicle transport

Identifiers

PMID34146484
PMCPMC8439105
OpenAlexW3172853464

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.