Evidence map›Paper›PMID 34146335›Full record

ArticleJournal of nephrology2021

Acute kidney injury, a common and severe complication in hospitalized patients during the COVID-19 pandemic.

Roberto Scarpioni, Teresa Valsania, Vittorio Albertazzi, Valentina Blanco, Sara DeAmicis, Alessandra Manini, Luigi Melfa, Marco Ricardi, Chiara Rocca, Stefano Gandolfi

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Mechanisms of SARS-CoV-2 Infection-Induced Kidney Injury: A Literature Review.Frontiers in cellular and infection microbiology · 2022
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Roberto ScarpioniDepartment of Nephrology and Dialysis, ASL "Guglielmo da Saliceto" Hospital Piacenza, via Taverna 49, 29121, Piacenza, Italy. r.scarpioni@ausl.pc.it.
Teresa ValsaniaDepartment of Nephrology and Dialysis, ASL "Guglielmo da Saliceto" Hospital Piacenza, via Taverna 49, 29121, Piacenza, Italy.
Vittorio AlbertazziDepartment of Nephrology and Dialysis, ASL "Guglielmo da Saliceto" Hospital Piacenza, via Taverna 49, 29121, Piacenza, Italy.
Valentina BlancoDepartment of Nephrology and Dialysis, ASL "Guglielmo da Saliceto" Hospital Piacenza, via Taverna 49, 29121, Piacenza, Italy.
Sara DeAmicisDepartment of Nephrology and Dialysis, ASL "Guglielmo da Saliceto" Hospital Piacenza, via Taverna 49, 29121, Piacenza, Italy.
Alessandra ManiniDepartment of Nephrology and Dialysis, ASL "Guglielmo da Saliceto" Hospital Piacenza, via Taverna 49, 29121, Piacenza, Italy.
Luigi MelfaDepartment of Nephrology and Dialysis, ASL "Guglielmo da Saliceto" Hospital Piacenza, via Taverna 49, 29121, Piacenza, Italy.
Marco RicardiDepartment of Nephrology and Dialysis, ASL "Guglielmo da Saliceto" Hospital Piacenza, via Taverna 49, 29121, Piacenza, Italy.
Chiara RoccaDepartment of Nephrology and Dialysis, ASL "Guglielmo da Saliceto" Hospital Piacenza, via Taverna 49, 29121, Piacenza, Italy.
Stefano GandolfiDepartment of Staff, ASL "Guglielmo da Saliceto" Hospital, Piacenza, Italy.
Guglielmo da Saliceto Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAcute respiratory failure (ARF) is the main clinical sign of coronavirus disease-2019 (COVID-19), but little is known about the outcome of acute kidney injury (AKI) associated with ARF. STUDY

designRetrospective cohort study on clinical features of adult patients hospitalized with COVID-19 between March 1st and April 30th, 2020 in the district of Piacenza (Italy).

resultsAmong 1894 hospitalized patients, 1701 affected by COVID-19 underwent at least two serum creatinine evaluations. According to KDIGO definitions, 233 of 1,701 patients (13.7%) developed AKI: 159, 34, and 40 had stage 1, 2 and 3 AKI, respectively. Patients with AKI were older (mean age 73.5 ± 14 years, range 24-95) than those without AKI (72 ± 14 years, range 20-102). In-hospital mortality was high in COVID patients (567/1701 patients, 33%), which almost doubled among AKI patients (132/233 patients, 57%), compared with those without AKI (p < 0.01). Risk factors for AKI included older age, male gender, diabetes and need for ventilation. Fourteen patients with stage 3 AKI underwent renal replacement therapy (RRT).

conclusionsHospitalized COVID-19 patients with AKI associated with ARF have poor chances of survival. Diagnosing and preventing the progression of renal damage is fundamental in order to delay initiating RRT, especially when resources are limited.

Indexed as

Acute Kidney InjuryCOVID-19AdultAgedAged, 80 and overFemaleHospital MortalityHumansMaleMiddle AgedPandemicsRetrospective StudiesRisk FactorsSARS-CoV-2Young AdultAcute kidney injuryAKI severityCOVID-19DialysisMortalityRenal replacement therapy

Identifiers

PMID34146335
PMCPMC8214067
OpenAlexW3171203272

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.