Evidence map›Paper›PMID 34146208›Full record

ArticleChild psychiatry and human development2022

Transgender Youth Executive Functioning: Relationships with Anxiety Symptoms, Autism Spectrum Disorder, and Gender-Affirming Medical Treatment Status.

John F Strang, Diane Chen, Eric Nelson, Scott F Leibowitz, Leena Nahata, Laura G Anthony, Amber Song, Connor Grannis, Elizabeth Graham, Shane Henise and 8 more

Abstract read
PubMed Publisher
In one paragraph

Article in Child psychiatry and human development, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Research methods at the intersection of gender diversity and autism: A scoping review.Autism : the international journal of research and practice · 2024
    Article
  7. Article
  8. Time is of the essence: Age at autism diagnosis, sex assigned at birth, and psychopathology.Autism : the international journal of research and practice · 2024
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Healthcare clinician perspectives on the intersection of autism and gender dysphoria.Autism : the international journal of research and practice · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 2 countries.

John F StrangDivision of Neuropsychology, Children's National Hospital, Washington, DC, USA. jstrang@childrensnational.org.ORCID 0000-0002-0950-6177
Diane ChenGender & Sex Development Program, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
Eric NelsonCenter for Biobehavioral Health, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, USA.
Scott F LeibowitzDivision of Psychiatry, Nationwide Children's Hospital, Columbus, OH, USA.
Leena NahataCenter for Biobehavioral Health, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, USA.
Laura G AnthonyDepartment of Psychiatry, University of Colorado School of Medicine, Aurora, CO, USA.
Amber SongGender Development Program, Children's National Hospital, Washington, DC, USA.
Connor GrannisCenter for Biobehavioral Health, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, USA.
Elizabeth GrahamThe Arc of the United States National Council of Self-Advocates, Washington, DC, USA.
Shane HeniseGender Development Program, Children's National Hospital, Washington, DC, USA.
Eric VilainCenter for Genetic Medicine Research, Youth Pride Clinic, Children's National Hospital, Washington, DC, USA.
Eleonora SadikovaCurry School of Education, University of Virginia, Charlottesville, VA, USA.
Andrew FreemanDepartment of Psychology, University of Nevada, Las Vegas, Las Vegas, NV, USA.
Cara PuglieseCenter for Neuroscience, Children's National Hospital, Washington, DC, USA.
Ayesha KhawajaDivision of Neuropsychology, Children's National Hospital, Washington, DC, USA.
Tekla MaisashviliDivision of Neuropsychology, Children's National Hospital, Washington, DC, USA.
Michael MancillaAdolescent and Young Adult Medicine, Youth Pride Clinic, Children's National Hospital, Washington, DC, USA.
Lauren KenworthyCenter for Neuroscience, Children's National Hospital, Washington, DC, USA.
Children's National · USNationwide Children's Hospital · USGeorge Washington University · USArc of the United States · USChildren's Hospital Colorado · USJefferson Hospital for Neuroscience · USNorthwestern University · USUniversity of Nevada, Las Vegas · USUniversity of Virginia · US

Funding

Clinical and Translational Science Institute at Childrens NationalUL1TR001876 · NCATS · CHILDREN'S RESEARCH INSTITUTE · PI BELL, MICHAEL J · 2016 to 2021
$25.6M
Clinical and Translational Science Institute at Childrens National-Mentored Career Development CoreKL2TR001877 · NCATS · CHILDREN'S RESEARCH INSTITUTE · PI LUBAN, NAOMI L · 2016 to 2020
$2.0M
NCATS NIH HHS KL2 TR001877NCATS NIH HHS UL1 TR001876
6 · The paper itself

Abstract

Executive function (EF) underlies broad health and adaptive outcomes. For transgender youth, navigating gender discernment and gender affirmation demand EF. Yet, factors associated with transgender youth EF are unknown. We investigate hypothesized predictors of EF: over-represented conditions among transgender youth (anxiety and depression symptoms, autism spectrum disorder [ASD]) and gender-affirming care. One-hundred twenty-four transgender 11-21-year-olds participated. Parents/caregivers completed EF and mental health report measures. ASD diagnostics and gender-affirming medication histories were collected. 21 % of non-autistic and 69 % of autistic transgender youth had clinically elevated EF problems. Membership in the gender-affirming hormone treatment group was associated with better EF. ASD, anxiety symptoms, and membership in the long-duration pubertal suppression group were associated with poorer EF. Given the importance of EF skills for multiple outcomes, and the unique and additional EF demands specific to transgender youths' experiences, EF skill monitoring-and when appropriate, supports-should be considered for transgender youth.

Indexed as

Autism Spectrum DisorderTransgender PersonsAdolescentAnxietyExecutive FunctionFemaleHormonesHumansMaleHormonesAutisticExecutive functionGender affirming hormonesGender diversityInternalizing

Identifiers

PMID34146208
OpenAlexW3166102221

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.