Evidence map›Paper›PMID 34146166›Full record

SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2021

The use of guarana (Paullinia cupana) as a dietary supplement for fatigue in cancer patients: a systematic review with a meta-analysis.

Daise Pereira de Araujo, Paula Tâmara Vieira Teixeira Pereira, Ariadina Jansen Campos Fontes, Karla Danielle Silva Marques, Érica Brandão de Moraes, Rosane Nassar Meireles Guerra, João Batista Santos Garcia

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Effect of Guarana (Nutrients · 2023
    Pooled it
  3. Article
  4. Review
  5. Management of Fatigue in Patients with Advanced Cancer.Current treatment options in oncology · 2023
    Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Daise Pereira de AraujoGraduate Program in Adult Health - Federal University of Maranhão-UFMA, Rua Munim, n° 001, Condomínio Vitré, BL 08 AP 304, São Luis, MA, CEP: 65070-017, Brazil. daise_araujo@msn.com.ORCID http://orcid.org/0000-0002-0649-7930
Paula Tâmara Vieira Teixeira PereiraGraduate Program in Adult Health - Federal University of Maranhão-UFMA, Av. dos Portugueses, 1966 - Vila Bacanga, São Luís, MA, CEP: 65065-545, Brazil.
Ariadina Jansen Campos FontesGraduate Program in Adult Health - Federal University of Maranhão-UFMA, Av. dos Portugueses, 1966 - Vila Bacanga, São Luís, MA, CEP: 65065-545, Brazil.
Karla Danielle Silva MarquesGraduate Program in Collective Health - Federal University of Maranhão-UFMA, Rua Barão de Itapary, Nº 155, Centro, São Luís, MA, CEP: 65020-070, Brazil.
Érica Brandão de MoraesFluminense Federal University, Niterói, Rio de Janeiro, Brazil.
Rosane Nassar Meireles GuerraImmunophysiology Laboratory of the Federal University of Maranhão-UFMA, Av. dos Portugueses, 1966 - Vila Bacanga, 65065545, São Luís, Brazil.
João Batista Santos GarciaAnaesthesiology, Pain and Palliative Care - Federal University of Maranhão, Av. dos Portugueses, 1966 - Vila Bacanga, São Luís, MA, CEP: 65065-545, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe objective of the present study was to carry out a systematic review with a meta-analysis to assess evidence about the use of guarana fruit to manage fatigue in cancer patients. METHODOLOGY: The data were extracted from the EMBASE, Scopus, MEDLINE, CENTRAL, and CINAHL databases, in any language, using the descriptors "neoplasms" and "Paullinia" or "guarana powder" and "placebos" and "fatigue". Searches were also conducted to identify any grey literature. Clinical studies with patients who presented cancer-related fatigue as a primary outcome and who used guarana as a dietary supplement were included. The risk of bias in randomized clinical trials was analyzed according to the Cochrane recommendations. The quality of the evidence was assessed using the GRADE system. For studies with the same types of tumors and treatments, meta-analysis was also conducted.

resultsA total of 383 studies were found and, of these, seven were included in the review, for a total of 427 cancer patients. The instruments used to analyze fatigue were the Brief Fatigue Inventory (BFI), the Chalder Fatigue Scale, the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-FATIGUE), and the Piper Scale. Some studies presented a low risk of bias for all the categories. Meta-analysis was conducted for three studies about breast cancer, which presented sufficient data. The use of guarana did not reduce cancer-related fatigue compared with placebo groups (mean of - 0.02 [95% CI - 1.54, 1.50]; p = 0.98) and the quality of evidence according to GRADE was very low.

conclusionDietary supplements are used to improve cancer-related fatigue. The results of this review showed that the use of guarana was not superior to the placebo groups, pointing to the need for further studies with better methodological quality.

Indexed as

Breast NeoplasmsPaulliniaDietary SupplementsFatigueFemaleHumansPlant ExtractsPlant ExtractsCancerClinical trialFatigueGuaranaPaullinia

Identifiers

PMID34146166

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.