ArticleAnnals of intensive care2021
Intra-dialytic hypotension following the transition from continuous to intermittent renal replacement therapy.
Article in Annals of intensive care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- [S3 guideline on renal replacement therapy in intensive care medicine : Evidence-based implementation of renal replacement therapy in critically ill patients].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2025Guideline
- Prevalence of cardiovascular instability during hemodialysis therapy in hospitalized patients: A systematic review and meta-analysis.Science progressPooled it
- Article
- Multidisciplinary guidelines on renal replacement therapy in intensive care medicine.Critical care (London, England) · 2026Review
- Machine learning model for predicting hypotension following continuous renal replacement therapy initiation in end-stage kidney disease patients: a SHAP-interpretable approach.Frontiers in medicine · 2026Article
- Intra-Dialytic Hypotension and the VExUS Assessment in Hospitalized Patients: A Prospective Cohort Study.Cardiorenal medicine · 2026Article
- Renal replacement therapy in intensive care unit: a narrative review.Annals of intensive care · 2026Review
- Intradialytic hypotension and worse outcomes in patients with acute kidney injury requiring intermittent hemodialysis.Kidney research and clinical practice · 2026Article
- [Ten key messages from the S3 guideline for evidence-based renal replacement therapy in intensive care medicine].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2025Review
- A machine learning model to predict intradialytic hypotension in pediatric continuous kidney replacement therapy.Pediatric nephrology (Berlin, Germany) · 2025Article
- Predictors of intradialytic hypotension in critically ill patients undergoing kidney replacement therapy: a systematic review.Intensive care medicine experimental · 2024Review
- Predicting intradialytic hypotension in critically ill patients undergoing intermittent hemodialysis: a prospective observational study.Intensive care medicine experimental · 2024Article
- Achievement of fluid removal targets during intermittent renal replacement therapy in the intensive care unit.Clinical kidney journal · 2024Article
- Validation of prediction model for successful discontinuation of continuous renal replacement therapy: a multicenter cohort study.Kidney research and clinical practice · 2024Article
- Syndecan-1 predicts hemodynamic instability in critically ill patients under intermittent hemodialysis.Clinical kidney journal · 2023Article
- Online Hemodiafiltration Compared to Conventional Hemodialysis in Critically Ill Patients.Kidney international reports · 2022Article
- Delivering optimal renal replacement therapy to critically ill patients with acute kidney injury.Intensive care medicine · 2022Review
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTransition from continuous renal replacement therapy (CRRT) to intermittent renal replacement therapy (IRRT) can be associated with intra-dialytic hypotension (IDH) although data to inform the definition of IDH, its incidence and clinical implications, are lacking. We aimed to describe the incidence and factors associated with IDH during the first IRRT session following transition from CRRT and its association with hospital mortality. This was a retrospective single-center cohort study in patients with acute kidney injury for whom at least one CRRT-to-IRRT transition occurred while in intensive care. We assessed associations between multiple candidate definitions of IDH and hospital mortality. We then evaluated the factors associated with IDH.
resultsWe evaluated 231 CRRT-to-IRRT transitions in 213 critically ill patients with AKI. Hospital mortality was 43.7% (n = 93). We defined IDH during the first IRRT session as 1) discontinuation of IRRT for hemodynamic instability; 2) any initiation or increase in vasopressor/inotropic agents or 3) a nadir systolic blood pressure of < 90 mmHg. IDH during the first IRRT session occurred in 50.2% of CRRT-to-IRRT transitions and was independently associated with hospital mortality (adjusted odds ratio [OR]: 2.71; CI 1.51-4.84, p < 0.001). Clinical variables at the time of CRRT discontinuation associated with IDH included vasopressor use, higher cumulative fluid balance, and lower urine output.
conclusionsIDH events during CRRT-to-IRRT transition occurred in nearly half of patients and were independently associated with hospital mortality. We identified several characteristics that anticipate the development of IDH following the initiation of IRRT.
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