Evidence map›Paper›PMID 34146144›Full record

ArticleDiabetologia2021

Potentially modifiable risk factors of preterm delivery in women with type 1 and type 2 diabetes.

Julie C Søholm, Marianne Vestgaard, Björg Ásbjörnsdóttir, Nicoline C Do, Berit W Pedersen, Lone Storgaard, Birgitte B Nielsen, Lene Ringholm, Peter Damm, Elisabeth R Mathiesen

Open access · bronzeAbstract read
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In one paragraph

Article in Diabetologia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Julie C SøholmCenter for Pregnant Women with Diabetes, Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0002-4936-8936
Marianne VestgaardCenter for Pregnant Women with Diabetes, Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0001-7358-8253
Björg ÁsbjörnsdóttirCenter for Pregnant Women with Diabetes, Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0002-0178-3663
Nicoline C DoCenter for Pregnant Women with Diabetes, Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0003-0868-5537
Berit W PedersenCenter for Pregnant Women with Diabetes, Rigshospitalet, Copenhagen, Denmark.
Lone StorgaardCenter for Pregnant Women with Diabetes, Rigshospitalet, Copenhagen, Denmark.
Birgitte B NielsenCenter for Pregnant Women with Diabetes, Rigshospitalet, Copenhagen, Denmark.
Lene RingholmCenter for Pregnant Women with Diabetes, Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0003-2971-8043
Peter DammCenter for Pregnant Women with Diabetes, Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0002-2067-5246
Elisabeth R MathiesenCenter for Pregnant Women with Diabetes, Rigshospitalet, Copenhagen, Denmark. Elisabeth.reinhardt.mathiesen@regionh.dk.ORCID 0000-0003-3279-0863
University of Copenhagen · DKRigshospitalet · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aims/hypothesisWe aimed to identify potentially modifiable risk factors and causes for preterm delivery in women with type 1 or type 2 (pre-existing) diabetes.

methodsA secondary analysis of a prospective cohort study of 203 women with pre-existing diabetes (117 type 1 and 86 type 2 diabetes) was performed. Consecutive singleton pregnancies were included at the first antenatal visit between September 2015 and February 2018.

resultsIn total, 27% (n = 55) of the 203 women delivered preterm at median 36 + 0 weeks. When stratified by diabetes type, 33% of women with type 1 diabetes delivered preterm compared with 20% in women with type 2 diabetes (p = 0.04). Women delivering preterm were characterised by a higher prevalence of pre-existing kidney involvement (microalbuminuria or diabetic nephropathy) (16% vs 3%, p = 0.002), preeclampsia (26% vs 5%, p < 0.001), higher positive ultrasound estimated fetal weight deviation at 27 gestational weeks (2.7% vs -1.6% from the mean, p = 0.008), higher gestational weight gain (399 g/week vs 329 g/week, p = 0.01) and similar HbA CONCLUSIONS/INTERPRETATIONS: Presence of preeclampsia, higher positive ultrasound estimated fetal weight deviation at 27 gestational weeks and higher gestational weight gain were independent potentially modifiable risk factors for preterm delivery in this cohort of women with pre-existing diabetes. Indicated preterm delivery was common with suspected fetal asphyxia or preeclampsia as the most prevalent causes. Prospective studies evaluating whether modifying these predictors will reduce the prevalence of preterm delivery are warranted.

Indexed as

Diabetes, GestationalDiabetes Mellitus, Type 2Pre-EclampsiaPremature BirthFemaleFetal MacrosomiaHumansInfant, NewbornPregnancyProspective StudiesRisk FactorsBlood pressureDiabetesFetal overgrowthGestational weight gainGlycaemic controlHypertensionPreeclampsiaPregnancy outcomePreterm delivery

Identifiers

PMID34146144
OpenAlexW3168198018

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.