ArticleMolecular biology and evolution2021
Chromosome Fusion Affects Genetic Diversity and Evolutionary Turnover of Functional Loci but Consistently Depends on Chromosome Size.
Article in Molecular biology and evolution, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43 citing papers in PubMed, 73 citations in OpenAlex.
- A population genomic resource for Drosophila pseudoobscura.G3 (Bethesda, Md.) · 2026Article
- Multilocus basis of incipient reproductive isolation in hybridizing populations is revealed by pangenomic and epigenetic divergence.Science advances · 2026Article
- A near telomere-to-telomere genome assembly of the Amur stickleback (Zoological research · 2026Article
- Population genomics ofbioRxiv : the preprint server for biology · 2026Article
- Genomic insights into chromosomal fusion and its evolutionary implications for zokors.Molecular biology and evolution · 2026Article
- Polygenic basis of incipient reproductive isolation in hybridizing populations is revealed by pangenomic and epigenetic divergence.bioRxiv : the preprint server for biology · 2025Article
- Article
- Lepidopteran Genomes Have Denser Transposable Elements in Smaller Chromosomes, Likely Driven by Non-allelic Homologous Recombination.Genome biology and evolution · 2025Article
- Multi-level genomic convergence of secondary aquatic adaptation in marine mammals.Innovation (Cambridge (Mass.)) · 2025Article
- Hierarchical architecture of neo-sex chromosomes and accelerated adaptive evolution in tortricid moths.Genome research · 2025Article
- Neo-Sex Chromosome Evolution in Treehoppers Despite Long-Term X Chromosome Conservation.Genome biology and evolution · 2024Article
- CAM evolution is associated with gene family expansion in an explosive bromeliad radiation.The Plant cell · 2024Article
- Impact of Chromosomal Fusion and Transposable Elements on the Genomic Evolution and Genetic Diversity ofPlants (Basel, Switzerland) · 2024Article
- Genomic evidence reveals three W-autosome fusions in Heliconius butterflies.PLoS genetics · 2024Article
- A macroevolutionary role for chromosomal fusion and fission inScience advances · 2024Article
- Comparative genomics reveals the dynamics of chromosome evolution in Lepidoptera.Nature ecology & evolution · 2024Article
- Chromosome-scale assembly of the streamlined picoeukaryoteMicrobial genomics · 2024Article
- Review
- Genomic insights into the chromosomal elongation in a family of Collembola.Proceedings. Biological sciences · 2024Article
- Automated recognition of chromosome fusion using an alignment-free natural vector method.Frontiers in genetics · 2024Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major changes in chromosome number and structure are linked to a series of evolutionary phenomena, including intrinsic barriers to gene flow or suppression of recombination due to chromosomal rearrangements. However, chromosome rearrangements can also affect the fundamental dynamics of molecular evolution within populations by changing relationships between linked loci and altering rates of recombination. Here, we build chromosome-level assembly Eueides isabella and, together with a recent chromosome-level assembly of Dryas iulia, examine the evolutionary consequences of multiple chromosome fusions in Heliconius butterflies. These assemblies pinpoint fusion points on 10 of the 20 autosomal chromosomes and reveal striking differences in the characteristics of fused and unfused chromosomes. The ten smallest autosomes in D. iulia and E. isabella, which have each fused to a longer chromosome in Heliconius, have higher repeat and GC content, and longer introns than predicted by their chromosome length. When fused, these characteristics change to become more in line with chromosome length. The fusions also led to reduced diversity, which likely reflects increased background selection and selection against introgression between diverging populations, following a reduction in per-base recombination rate. We further show that chromosome size and fusion impact turnover rates of functional loci at a macroevolutionary scale. Together these results provide further evidence that chromosome fusion in Heliconius likely had dramatic effects on population level processes shaping rates of neutral and adaptive divergence. These effects may have impacted patterns of diversification in Heliconius, a classic example of an adaptive radiation.
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