Evidence map›Paper›PMID 34145793›Full record

ArticleCancer medicine2021

Methylation of three genes encoded by X chromosome in blood leukocytes and colorectal cancer risk.

Tian Tian, Haoran Bi, Ding Zhang, Yupeng Liu, Hongru Sun, Chenyang Jia, Ting Zheng, Hao Huang, Jinming Fu, Lin Zhu and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Genetic and Epigenetic Association ofInternational journal of molecular sciences · 2024
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Tian TianDepartment of Epidemiology, Public Health College, Harbin Medical University, Harbin, Heilongjiang, The People's Republic of China.ORCID 0000-0002-3686-173X
Haoran BiDepartment of Epidemiology, Public Health College, Harbin Medical University, Harbin, Heilongjiang, The People's Republic of China.
Ding ZhangDepartment of Epidemiology, Public Health College, Harbin Medical University, Harbin, Heilongjiang, The People's Republic of China.
Yupeng LiuDepartment of Epidemiology, Public Health College, Harbin Medical University, Harbin, Heilongjiang, The People's Republic of China.
Hongru SunDepartment of Epidemiology, Public Health College, Harbin Medical University, Harbin, Heilongjiang, The People's Republic of China.
Chenyang JiaDepartment of Epidemiology, Public Health College, Harbin Medical University, Harbin, Heilongjiang, The People's Republic of China.
Ting ZhengDepartment of Epidemiology, Public Health College, Harbin Medical University, Harbin, Heilongjiang, The People's Republic of China.
Hao HuangDepartment of Epidemiology, Public Health College, Harbin Medical University, Harbin, Heilongjiang, The People's Republic of China.
Jinming FuDepartment of Epidemiology, Public Health College, Harbin Medical University, Harbin, Heilongjiang, The People's Republic of China.
Lin ZhuDepartment of Epidemiology, Public Health College, Harbin Medical University, Harbin, Heilongjiang, The People's Republic of China.ORCID 0000-0001-6759-1069
Yashuang ZhaoDepartment of Epidemiology, Public Health College, Harbin Medical University, Harbin, Heilongjiang, The People's Republic of China.ORCID 0000-0002-7425-5773
Harbin Medical University · CN

Funding

Heilongjiang Provincial Natural Science Foundation of China LH2020H019Ordinary Universities of the Education Department of Heilongjiang Province UNPYSCT-2017049Youth Innovative Talents Training ProgramYouth Innovative Talents Training Program in Ordinary Universities of the Education Department of Heilongjiang Province UNPYSCT-2017049
6 · The paper itself

Abstract

X chromosome change has been proved to be associated with carcinogenesis and related to gender differences in cancer risk. If aberrant methylation of genes encoded by X chromosome involve in the risk and prognosis of cancers, including colorectal cancer (CRC), remain unclear. We conducted a case-control study consisted of 432 CRC cases and 434 controls, detecting the methylation levels of FAM156B, PIH1D3, and PPP1R3F in the X chromosome in blood leukocytes using methylation-sensitive high-resolution melting (MS-HRM). We analyzed the relationship between the methylation levels and CRC susceptibility and then explored the interactions with environmental factors on CRC risk with logistics regression. Moreover, we conducted a follow-up study containing 225 CRC patients to explore the associations between the methylation of FAM156B, PPP1R3F, and PIH1D3 and CRC prognosis. The hypermethylation of FAM156B, PPP1R3F, and PIH1D3 was related to increased CRC risk (OR

Indexed as

DNA MethylationLeukocytesAdultAgedCase-Control StudiesChromosomes, Human, XColorectal NeoplasmsFemaleGene-Environment InteractionHumansIntracellular Signaling Peptides and ProteinsLogistic ModelsMaleMembrane ProteinsMiddle AgedPhosphoprotein PhosphatasesDNAAF6 protein, humanIntracellular Signaling Peptides and ProteinsMembrane ProteinsPhosphoprotein Phosphatasescolorectal cancerDNA methylationFAM156BPIH1D3PPP1R3F

Identifiers

PMID34145793
PMCPMC8290255
OpenAlexW3166539974

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.