Evidence map›Paper›PMID 34145705›Full record

ArticleAngewandte Chemie (International ed. in English)2021

Enantioselective Addition of Pyrazoles to Dienes*.

Alexander Y Jiu, Hannah S Slocumb, Charles S Yeung, Xiao-Hui Yang, Vy M Dong

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Synthesis of 1,3-Dienes from Alkenes via Alkenyl Thianthrenium Salts.Journal of the American Chemical Society · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Palladium-catalyzed remote internal C(spNature communications · 2024
    Article
  8. Article
  9. Article
  10. Asymmetric formal spNature communications · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Enantioselective Hydroalkoxylation of 1,3-Dienes via Ni-Catalysis.Journal of the American Chemical Society · 2023
    Article
  15. Article
  16. CsRSC advances · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alexander Y JiuDepartment of Chemistry, University of California, Irvine, Irvine, CA, 92697, USA.ORCID 0000-0003-3275-3085
Hannah S SlocumbDepartment of Chemistry, University of California, Irvine, Irvine, CA, 92697, USA.ORCID 0000-0002-9440-2195
Charles S YeungDiscovery Chemistry, Merck & Co., Inc., Boston, MA, 02115, USA.ORCID 0000-0001-7320-7190
Xiao-Hui YangAdvanced Research Institute of Multidisciplinary Science, and School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081, China.
Vy M DongDepartment of Chemistry, University of California, Irvine, Irvine, CA, 92697, USA.ORCID 0000-0002-8099-1048

Funding

Innovative Tools for Chemical Synthesis: Metal-Hydride Catalysis, Medicinal Motifs, and Molecular ProbesR35GM127071 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Vy M Dong · 2018 to 2026
$4.9M
NIGMS NIH HHS R35 GM127071
6 · The paper itself

Abstract

We report the first enantioselective addition of pyrazoles to 1,3-dienes. Secondary and tertiary allylic pyrazoles can be generated with excellent regioselectivity. Mechanistic studies support a pathway distinct from previous hydroaminations: a Pd

Indexed as

AlkadienesCatalysisLigandsMolecular StructurePalladiumPyrazolesStereoisomerismAlkadienesLigandsPalladiumPyrazoles1,3-dieneenantioselectivityhydroaminationPd-catalysispyrazole

Identifiers

PMID34145705
PMCPMC8889753

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.