ArticleAngewandte Chemie (International ed. in English)2021
Non-Invasive Sweat-Based Tracking of L-Dopa Pharmacokinetic Profiles Following an Oral Tablet Administration.
Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 95 citations in OpenAlex.
- Wearable bioelectronics enabled by conductive hydrogels: From materials innovation to clinical translation.Materials today. Bio · 2026Review
- Microneedle-Based Continuous Levodopa Monitoring in Patients with Parkinson's Disease.ACS sensors · 2026Article
- Wearable sensors for monitoring drug pharmacokinetics in patients with Parkinson's disease.Scientific reports · 2026Article
- Article
- Body Biofluids for Minimally-Invasive Diagnostics: Insights, Challenges, Emerging Technologies, and Clinical Potential.Advanced healthcare materials · 2026Review
- A nanoMIP sensor for real-time in vivo monitoring of levodopa pharmacokinetics in precision Parkinson's therapy.Nature communications · 2025Article
- Printed Sensors for Quantifying Electrodermal Activity and Sweat Rate: A Review.Sensors (Basel, Switzerland) · 2025Review
- Smart closed-loop drug delivery systems.Nature reviews bioengineering · 2025Article
- A bioinspired microfluidic wearable sensor for multiday sweat sampling, transport, and metabolic analysis.Science advances · 2025Article
- Microneedle-based integrated pharmacokinetic and pharmacodynamic evaluation platform for personalized medicine.Nature communications · 2025Article
- A Touch Enabled Hemodynamic and Metabolic Monitor.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- An epidermal serine sensing system for skin healthcare.Nature communications · 2025Article
- Smartphone Biosensors for Non-Invasive Drug Monitoring in Saliva.Biosensors · 2025Article
- Advances in hydrogel for diagnosis and treatment for Parkinson's disease.Frontiers in pharmacology · 2025Review
- Biochemical Sensors for Personalized Therapy in Parkinson's Disease: Where We Stand.Journal of clinical medicine · 2024Review
- A Passive Perspiration Inspired Wearable Platform for Continuous Glucose Monitoring.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Diving into Sweat: Advances, Challenges, and Future Directions in Wearable Sweat Sensing.ACS nano · 2024Review
- Levodopa: From Biological Significance to Continuous Monitoring.ACS sensors · 2024Review
- Biosensor Strip for Rapid On-site Assessment of Levodopa Pharmacokinetics along with Motor Performance in Parkinson's Disease.Angewandte Chemie (International ed. in English) · 2024Article
- Approaches of wearable and implantable biosensor towards of developing in precision medicine.Frontiers in medicine · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Levodopa (L-Dopa) is the "gold-standard" medication for symptomatic therapy of Parkinson disease (PD). However, L-Dopa long-term use is associated with the development of motor and non-motor complications, primarily due to its fluctuating plasma levels in combination with the disease progression. Herein, we present the first example of individualized therapeutic drug monitoring for subjects upon intake of standard L-Dopa oral pill, centered on dynamic tracking of the drug concentration in naturally secreted fingertip sweat. The touch-based non-invasive detection method relies on instantaneous collection of fingertip sweat on a highly permeable hydrogel that transports the sweat to a biocatalytic tyrosinase-modified electrode, where sweat L-Dopa is measured by reduction of the dopaquinone enzymatic product. Personalized dose-response relationship is demonstrated within a group of human subjects, along with close pharmacokinetic correlation between the finger touch-based fingertip sweat and capillary blood samples.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.