Evidence map›Paper›PMID 34145702›Full record

ArticleInternational journal of clinical practice2021

COVID-19 and celiac disease: A pathogenetic hypothesis for a celiac outbreak.

Chiara Maria Trovato, Monica Montuori, Nicoletta Pietropaoli, Salvatore Oliva

Open access · greenAbstract read
In one paragraph

Article in International journal of clinical practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Viruses and celiac disease: what do we know ?Clinical and experimental medicine · 2023
    Pooled it
  2. Article
  3. Article
  4. Review
  5. Inflammatory Arthritis After COVID-19: A Case Series.The American journal of case reports · 2023
    Article
  6. Article
  7. Review
  8. COVID-19 and celiac disease: a review.Therapeutic advances in gastroenterology · 2023
    Review
  9. Review
  10. New-onset celiac disease in children during COVID-19 pandemic.Acta paediatrica (Oslo, Norway : 1992) · 2022
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Chiara Maria TrovatoPediatric Gastroenterology and Liver Unit, Maternal and Child Health Department, Sapienza University of Rome, Rome, Italy.ORCID https://orcid.org/0000-0003-3869-1815
Monica MontuoriPediatric Gastroenterology and Liver Unit, Maternal and Child Health Department, Sapienza University of Rome, Rome, Italy.
Nicoletta PietropaoliPediatric Gastroenterology and Liver Unit, Maternal and Child Health Department, Sapienza University of Rome, Rome, Italy.
Salvatore OlivaPediatric Gastroenterology and Liver Unit, Maternal and Child Health Department, Sapienza University of Rome, Rome, Italy.
Sapienza University of Rome · ITBambino Gesù Children's Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA growing body of evidence supports the intestinal trophism of SARS-CoV-2, with ciliated cells and intestinal enterocytes being target cells because of the high expression of ACE2 and TMPRSS2. Indeed, COVID-19 promotes a "cytokine storm" in the intestinal mucosa: the resulting epithelial damage leads to increased barrier permeability, allowing the passage of gliadin in the intestinal lamina.

methodsBased on current literature, we hypothesize the role of COVID-19 as a potential trigger factor for celiac disease in predisposed patients.

conclusionsGenetically predisposed patients could be more likely to develop celiac disease following SARS-CoV-2 infection, making COVID-19 a candidate culprit for a potential outbreak of celiac disease in the forthcoming future.

Indexed as

Celiac DiseaseCOVID-19Disease OutbreaksGliadinHumansSARS-CoV-2Gliadin

Identifiers

PMID34145702
PMCPMC8420168
OpenAlexW3167203305

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.