Evidence map›Paper›PMID 34145635›Full record

ArticleMovement disorders : official journal of the Movement Disorder Society2021

Childhood-Onset Chorea Caused by a Recurrent De Novo DRD2 Variant.

Niccolò E Mencacci, Dora Steel, Francesca Magrinelli, Jerry Hsu, Ignacio Juan Keller Sarmiento, Mónica Troncoso Schifferli, Daniela Muñoz, Leonidas Stefanis, Steven J Lubbe, Nicholas W Wood and 2 more

Abstract readLetterComment
PubMed Publisher
In one paragraph

Article in Movement disorders : official journal of the Movement Disorder Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Cardiovascular pharmacology of dopaminergic agents in humans: a review.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Review
  2. Update on Genetic Chorea.Current neurology and neuroscience reports · 2026
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 6 countries.

Niccolò E MencacciKen and Ruth Davee Department of Neurology and Simpson Querrey Center for Neurogenetics, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.ORCID 0000-0003-3383-9665
Dora SteelMolecular Neurosciences, Developmental Neurosciences, University College London Great Ormond Street Institute of Child Health, London, United Kingdom.
Francesca MagrinelliDepartment of Clinical and Movement Neurosciences, University College London Queen Square Institute of Neurology, University College London, London, United Kingdom.ORCID 0000-0003-4706-6245
Jerry HsuKen and Ruth Davee Department of Neurology and Simpson Querrey Center for Neurogenetics, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.
Ignacio Juan Keller SarmientoKen and Ruth Davee Department of Neurology and Simpson Querrey Center for Neurogenetics, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.
Mónica Troncoso SchifferliChild Neurology Service, Clinical Hospital San Borja Arriarán, Faculty of Medicine, University of Chile, Santiago, Chile.
Daniela MuñozChild Neurology Service, Clinical Hospital San Borja Arriarán, Faculty of Medicine, University of Chile, Santiago, Chile.
Leonidas Stefanis1st Neurology Clinic, Eginition Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
Steven J LubbeKen and Ruth Davee Department of Neurology and Simpson Querrey Center for Neurogenetics, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.
Nicholas W WoodDepartment of Clinical and Movement Neurosciences, University College London Queen Square Institute of Neurology, University College London, London, United Kingdom.
Manju A KurianMolecular Neurosciences, Developmental Neurosciences, University College London Great Ormond Street Institute of Child Health, London, United Kingdom.ORCID 0000-0003-3529-5075
Maria Stamelou1st Neurology Clinic, Eginition Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece.ORCID 0000-0003-1668-9925
Northwestern University · USGreat Ormond Street Hospital · GBHospital San Borja Arriarán · CLNational and Kapodistrian University of Athens · GRQueen Mary University of London · GBUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ChoreaDystoniaChildGain of Function MutationHumansPhenotypeReceptors, Dopamine D2DRD2 protein, humanReceptors, Dopamine D2choreadopamine receptorDRD2Huntington disease-like syndrome

Identifiers

PMID34145635
OpenAlexW3169462207

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.