Evidence map›Paper›PMID 34145535›Full record

ArticleMolecular biology reports2021

Effects of mesenchymal stem cell-derived exosomes on oxidative stress responses in skin cells.

Takaaki Matsuoka, Keita Takanashi, Katsuaki Dan, Kenichi Yamamoto, Koji Tomobe, Tatsuo Shinozuka

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Exosome is a Fancy Mobile Sower of Ferroptosis.Journal of cardiovascular translational research · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Stem Cell-Derived Exosomes: A New Method for Reversing Skin Aging.Tissue engineering and regenerative medicine · 2022
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Takaaki MatsuokaOmotesando Helene Clinic, 3F Aoyama OHMOTO Building, 5-9-15 Minamiaoyama, Minato-ku, Tokyo, 107-0062, Japan. matsuoka@stemcells.jp.ORCID http://orcid.org/0000-0002-5466-2857
Keita TakanashiDepartment of Center for Pharmaceutical Education, Yokohama University of Pharmacy, Yokohama-shi, Kanagawa, Japan.
Katsuaki DanDivision of Research and Development, Research Organization of Biological Activity, Toshima-ku, Tokyo, Japan.
Kenichi YamamotoReal Mate Co. Ltd., Nagoya-shi, Aichi, Japan.
Koji TomobeDepartment of Pathophysiology, Yokohama University of Pharmacy, Yokohama-shi, Kanagawa, Japan.
Tatsuo ShinozukaDepartment of Pathophysiology, Yokohama University of Pharmacy, Yokohama-shi, Kanagawa, Japan.
Yokohama University of Pharmacy · JPMinamiaoyama Eye Clinic · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mechanism by which reactive oxygen species (ROS) produced by oxidative stress promote cellular senescence has been studied in detail. This study aimed to verify the preventive or therapeutic effects of mesenchymal stem cell-derived exosomes (MSC-Ex) on the production of ROS induced by oxidative stress in human skin fibroblasts and clarify the mechanisms that promote cellular senescence. In a system where H

Indexed as

Aquaporin 1Aquaporin 3Cellular SenescenceCyclin-Dependent Kinase Inhibitor p21ExosomesFibroblastsGene Expression Regulation, DevelopmentalHumansHydrogen PeroxideMesenchymal Stem CellsOxidative StressReactive Oxygen SpeciesSignal TransductionSirtuin 1SkinTumor Suppressor Protein p53AQP1 protein, humanAquaporin 1Aquaporin 3CDKN1A protein, humanCyclin-Dependent Kinase Inhibitor p21Hydrogen PeroxideReactive Oxygen SpeciesSIRT1 protein, humanSirtuin 1TP53 protein, humanTumor Suppressor Protein p53ExosomeFibroblastsMesenchymal stem cellsOxidative stressReactive oxygen speciesβ-Galactosidase

Identifiers

PMID34145535
OpenAlexW3168063180

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.