Evidence map›Paper›PMID 34145489›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2021

Oral health condition in cancer patients under bisphosphonate therapy.

Rogério Jardim Caldas, Héliton Spíndola Antunes, Camila de Oliveira Rodini Pegoraro, Fábio Ribeiro Guedes, Paulo Sérgio da Silva Santos

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. A retrospective cohort study of the oral healthcare needs of cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Rogério Jardim CaldasDepartment of Dentistry, Mario Kroeff Hospital, Rio de Janeiro, Brazil. dr.rogeriocaldas@gmail.com.ORCID http://orcid.org/0000-0001-6410-0551
Héliton Spíndola AntunesDivision of Clinical Research and Technological Development, National Institute of Cancer, Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0002-1076-8019
Camila de Oliveira Rodini PegoraroDepartment of Biological Sciences, University of Sao Paulo, Bauru School of Dentistry, Bauru, Brazil.ORCID http://orcid.org/0000-0002-8763-4967
Fábio Ribeiro GuedesFaculty of Dentistry, Department of Pathology and Oral Diagnosis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Paulo Sérgio da Silva SantosDepartment of Surgery, Stomatology, Pathology and Radiology, University of Sao Paulo, Bauru School of Dentistry, Alameda Dr. Octávio Pinheiro Brisolla, 9-75, Bauru, São Paulo, 17012-901, Brazil.ORCID http://orcid.org/0000-0002-0674-3759
Universidade de São Paulo · BRInstituto Nacional de Câncer - INCA · BRUniversidade Federal do Rio de Janeiro · BR

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001
6 · The paper itself

Abstract

objectivesTo investigate the association of oral health condition with the occurrence of medication-related osteonecrosis of the jaw (MRONJ) in a cancer population.

methodsA multicenter cross-sectional study was conducted with cancer patients exposed to bisphosphonates for at least 7 months. Dental and periodontal conditions were assessed by epidemiological indices.

resultsThe sample consisted of 80 patients under bisphosphonate therapy, nine of which were allocated to group 1 (with MRONJ) and 71 to group 2 (without MRONJ). Osteonecrosis cases presented 19 decayed, missing, and filled teeth on average. Moderate gingival inflammation was noted in both groups and together with severe inflammation exceeded 50% of the groups. The presence of dental calculus was detected in about half of the individuals in both groups. Shallow periodontal pockets were detected in about 25% of both groups. Deep periodontal pockets were more prevalent among patients with osteonecrosis. Regular oral hygiene was detected in approximately 25% of individuals in both groups. There was a strong positive correlation between the clinical staging of osteonecrosis and decayed, missing, and filled teeth index (DMFTI).

conclusionsPatients had a poor oral health condition. All but one osteonecrosis case had no previous history of tooth extraction; oral infections seemed to play a major role in the development of bone necrosis. Advanced osteonecrosis stages were associated with a higher DMFTI.

Indexed as

Bisphosphonate-Associated Osteonecrosis of the JawBone Density Conservation AgentsNeoplasmsCross-Sectional StudiesDiphosphonatesHumansOral HealthBone Density Conservation AgentsDiphosphonatesCariesEpidemiologyOncologyOral hygieneOsteonecrosisPeriodontal disease(s)/periodontitis

Identifiers

PMID34145489
OpenAlexW3170685084

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.