Evidence map›Paper›PMID 34145431›Full record

ReviewNature reviews. Neurology2021

Diagnosis and management of migraine in ten steps.

Anna K Eigenbrodt, Håkan Ashina, Sabrina Khan, Hans-Christoph Diener, Dimos D Mitsikostas, Alexandra J Sinclair, Patricia Pozo-Rosich, Paolo Martelletti, Anne Ducros, Michel Lantéri-Minet and 17 more

2 registry-linked trialsOpen access · hybridAbstract readReviewConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 277 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
277citing papers in PubMed, 14 pooled it
56.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06109389 phase2unknown statusnot on this mapstarted 2023, after this paper: background citation

The Efficacy of Intravenous Lidocaine Infusion in Chronic Unilateral Migraine Headache Clinical and Laboratory Assessment .Aprospective Randomized Double Blind Controlled Study

TypeinterventionalSponsorAlexandria UniversityRan2023 to 2024Enrolled80ConditionsChronic Migraine, HeadacheArmsLidocaine IV
NCT06203678 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Investigation of the Effectiveness of Cervical Kinesio Taping Taping Application on Headache Symptoms in Migraine.

TypeinterventionalSponsorSultan Abdulhamid Han Training and Research Hospital, Istanbul, TurkeyRan2024 to 2025Enrolled18ConditionsMigraine, Kinesio TapingArmsKinesio taping, Exercise, Sham taping
3 · Its place in the literature

Who cites it

277 citing papers in PubMed, 14 syntheses or guidelines pooled it, 546 citations in OpenAlex.

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  8. What does a migraine aura look like?-A systematic review.The journal of headache and pain · 2025
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  15. Neurovascular-immune mediator dynamics in migraine: State-dependent effects of caffeine.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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217 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors at 20 institutions in 17 countries.

Anna K Eigenbrodt *Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-5031-8971
Håkan Ashina *Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Sabrina KhanDanish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-0953-5701
Hans-Christoph DienerInstitute for Medical Informatics, Biometry and Epidemiology, Medical Faculty, University Duisburg-Essen, Essen, Germany.ORCID http://orcid.org/0000-0002-6556-8612
Dimos D MitsikostasFirst Department of Neurology, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Alexandra J SinclairMetabolic Neurology, Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0003-2777-5132
Patricia Pozo-RosichHeadache Unit, Neurology Department, Vall d'Hebron University Hospital, Barcelona, Spain.ORCID http://orcid.org/0000-0003-0796-4702
Paolo MartellettiDepartment of Clinical and Molecular Medicine, Sapienza University, Rome, Italy.ORCID http://orcid.org/0000-0002-6556-4128
Anne DucrosNeurology Department, Montpellier University Hospital, Montpellier, France.ORCID http://orcid.org/0000-0001-5560-5013
Michel Lantéri-MinetDepartement d'Evaluation et Traitement de la Douleur, Centre Hospitalo-Universitaire de Nice, Nice, France.
Mark BraschinskyNeurology Clinic, Tartu University Hospital, Tartu, Estonia.ORCID http://orcid.org/0000-0002-3457-0242
Margarita Sanchez Del RioDepartment of Neurology, Clínica Universidad de Navarra, Madrid, Spain.
Oved DanielHeadache & Facial Pain Clinic, Laniado Medical Center, Netanya, Israel.ORCID http://orcid.org/0000-0002-8232-9138
Aynur ÖzgeDepartment of Neurology, Mersin University Medical Faculty, Mersin, Turkey.ORCID http://orcid.org/0000-0003-2797-2398
Ayten MammadbayliDepartment of Neurology, Azerbaijan State Medical University, Baku, Azerbaijan.
Mihails AronsDepartment of Anesthesiology and Intensive Care, P. Stradins University, Riga, Latvia.ORCID http://orcid.org/0000-0002-3888-2630
Kirill SkorobogatykhUniversity Headache Clinic, Moscow, Russia.ORCID http://orcid.org/0000-0002-1279-9548
Vladimir RomanenkoUkrainian Institute of Family Medicine, Kiev, Ukraine.
Gisela M TerwindtDepartment of Neurology, Leiden University Medical Center, Leiden, Netherlands.
Koen PaemeleireDepartment of Neurology, Ghent University Hospital, Ghent, Belgium.ORCID http://orcid.org/0000-0001-8103-3899
Simona SaccoNeuroscience Section, Department of Applied Clinical Sciences and Biotechnology, University of L'Aquila, L'Aquila, Italy.ORCID http://orcid.org/0000-0003-0651-1939
Uwe ReuterDepartment of Neurology, Charité Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0002-8527-0725
Christian LamplHeadache Medical Center, Seilerstaette Linz, Linz, Austria.
Henrik W SchytzDanish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-6262-2986
Zaza KatsaravaDepartment of Neurology, University of Duisburg-Essen, Essen, Germany.ORCID http://orcid.org/0000-0002-9932-1159
Timothy J SteinerDepartment of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, NTNU Norwegian University of Science and Technology, Trondheim, Norway.ORCID http://orcid.org/0000-0002-1882-4337
Messoud AshinaDanish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. ashina@dadlnet.dk.
University of Copenhagen · DKAzerbaijan Medical University · AZCentre Hospitalier Universitaire de Nice · FRCharité - Universitätsmedizin Berlin · DEClinica Universidad de Navarra · ESCTO Andrea Alesini · ITGhent University Hospital · BEKepler Universitätsklinikum · ATLaniado Hospital · ILLeiden University Medical Center · NLMersin Üniversitesi · TRNational and Kapodistrian University of Athens · GRNorwegian University of Science and Technology · NORiga Stradiņš University · LVSechenov University · RUTartu University Hospital · EEUniversitat Autònoma de Barcelona · ESUniversité de Montpellier · FRUniversity Hospitals Birmingham NHS Foundation Trust · GBUniversity of Duisburg-Essen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Migraine is a disabling primary headache disorder that directly affects more than one billion people worldwide. Despite its widespread prevalence, migraine remains under-diagnosed and under-treated. To support clinical decision-making, we convened a European panel of experts to develop a ten-step approach to the diagnosis and management of migraine. Each step was established by expert consensus and supported by a review of current literature, and the Consensus Statement is endorsed by the European Headache Federation and the European Academy of Neurology. In this Consensus Statement, we introduce typical clinical features, diagnostic criteria and differential diagnoses of migraine. We then emphasize the value of patient centricity and patient education to ensure treatment adherence and satisfaction with care provision. Further, we outline best practices for acute and preventive treatment of migraine in various patient populations, including adults, children and adolescents, pregnant and breastfeeding women, and older people. In addition, we provide recommendations for evaluating treatment response and managing treatment failure. Lastly, we discuss the management of complications and comorbidities as well as the importance of planning long-term follow-up.

Indexed as

ConsensusDisease ManagementClinical Decision-MakingDenmarkHumansMigraine DisordersPractice Guidelines as TopicSocieties, Medical

Identifiers

PMID34145431
PMCPMC8321897
OpenAlexW3166381176

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.