Evidence map›Paper›PMID 34145402›Full record

ArticleThe pharmacogenomics journal2021

Pharmacoepigenomics circuits induced by a novel retinoid-polyamine conjugate in human immortalized keratinocytes.

Katerina Grafanaki, Ilias Skeparnias, Christos K Kontos, Dimitrios Anastasakis, Aigli Korfiati, George Kyriakopoulos, Konstantinos Theofilatos, Seferina Mavroudi, George Magoulas, Dionissios Papaioannou and 3 more

Abstract read
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In one paragraph

Article in The pharmacogenomics journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Katerina GrafanakiDepartment of Biochemistry, School of Medicine, University of Patras, Patras, Greece.
Ilias SkeparniasDepartment of Biochemistry, School of Medicine, University of Patras, Patras, Greece.ORCID http://orcid.org/0000-0003-1188-529X
Christos K KontosDepartment of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, Athens, Greece.ORCID http://orcid.org/0000-0002-9935-8461
Dimitrios AnastasakisDepartment of Biochemistry, School of Medicine, University of Patras, Patras, Greece.
Aigli KorfiatiDepartment of Medical Physics, School of Medicine, University of Patras, Patras, Greece.
George KyriakopoulosDepartment of Biochemistry, School of Medicine, University of Patras, Patras, Greece.ORCID http://orcid.org/0000-0002-5628-6138
Konstantinos TheofilatosInSyBio Ltd,19 Staple Gardens SO23 8SR, Winchester, Hampshire, UK.
Seferina MavroudiInSyBio Ltd,19 Staple Gardens SO23 8SR, Winchester, Hampshire, UK.
George MagoulasDepartment of Chemistry, University of Patras, Patras, Greece.
Dionissios PapaioannouDepartment of Chemistry, University of Patras, Patras, Greece.
Andreas ScorilasDepartment of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, Athens, Greece.
Constantinos StathopoulosDepartment of Biochemistry, School of Medicine, University of Patras, Patras, Greece. cstath@med.upatras.gr.
Denis DrainasDepartment of Biochemistry, School of Medicine, University of Patras, Patras, Greece. drainas@med.upatras.gr.
University of Patras · GRNational and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Retinoids are widely used in diseases spanning from dermatological lesions to cancer, but exhibit severe adverse effects. A novel all-trans-Retinoic Acid (atRA)-spermine conjugate (termed RASP) has shown previously optimal in vitro and in vivo anti-inflammatory and anticancer efficacy, with undetectable teratogenic and toxic side-effects. To get insights, we treated HaCaT cells which resemble human epidermis with IC

Indexed as

TranscriptomeApoptosisCell ProliferationDose-Response Relationship, DrugGene Regulatory NetworksHaCaT CellsHumansInhibitory Concentration 50KeratinocytesMicroRNAsProtein Interaction MapsSignal TransductionSpermineTretinoinMicroRNAsN1,N12-bis(retinoyl)spermineSpermineTretinoin

Identifiers

PMID34145402
OpenAlexW3168706498

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.