Evidence map›Paper›PMID 34145393›Full record

ReviewMolecular psychiatry2022

Application of optogenetics and in vivo imaging approaches for elucidating the neurobiology of addiction.

Casey R Vickstrom, Shana Terai Snarrenberg, Vladislav Friedman, Qing-Song Liu

Abstract readReview
In one paragraph

Review in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. [Establishment and evaluation of rat and mouse models with addictive behaviors].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Review
  3. Article
  4. Article
  5. Targeting the insular cortex for neuropathic pain modulation: Insights into synaptic and neuronal mechanisms.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Casey R Vickstrom *Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA. cvickstrom@mcw.edu.ORCID http://orcid.org/0000-0003-0536-1211
Shana Terai Snarrenberg *Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.ORCID http://orcid.org/0000-0003-1439-0313
Vladislav FriedmanDepartment of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.ORCID http://orcid.org/0000-0002-5567-2520
Qing-Song LiuDepartment of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA. qsliu@mcw.edu.ORCID http://orcid.org/0000-0003-1858-1504

Funding

Medical Scientist Training ProgramT32GM080202 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI BARBIERI, JOSEPH T, SALZMAN, NITA H · 2010 to 2024
$5.7M
Mechanistic studies of phosphodiesterase inhibitors in cocaine addictionR01DA035217 · NIDA · MEDICAL COLLEGE OF WISCONSIN · PI LIU, QING-SONG · 2014 to 2023
$3.4M
Circuit-specific actions of endocannabinoids in stress and mood disordersR01MH121454 · NIMH · MEDICAL COLLEGE OF WISCONSIN · PI HILLARD, CECILIA J, LIU, QING-SONG · 2019 to 2023
$1.9M
Zona Incerta Contributions to Reward and Cocaine AddictionR01DA047269 · NIDA · MEDICAL COLLEGE OF WISCONSIN · PI LIU, QING-SONG · 2019 to 2023
$1.8M
Endocannabinoid regulation of a septohabenular circuit in anxiety and depressionF30MH115536 · NIMH · MEDICAL COLLEGE OF WISCONSIN · PI VICKSTROM, CASEY R · 2017 to 2021
$237k
Regulation of neuronal activity in the paraventricular thalamus by chronic morphineF31DA054759 · NIDA · MEDICAL COLLEGE OF WISCONSIN · PI FRIEDMAN, VLADISLAV · 2021 to 2024
$189k
NIDA NIH HHS F31 DA054759NIDA NIH HHS R01 DA035217NIDA NIH HHS R01 DA047269NIGMS NIH HHS T32 GM080202NIMH NIH HHS F30 MH115536NIMH NIH HHS R01 MH121454
6 · The paper itself

Abstract

The neurobiology of addiction has been an intense topic of investigation for more than 50 years. Over this time, technological innovation in methods for studying brain function rapidly progressed, leading to increasingly sophisticated experimental approaches. To understand how specific brain regions, cell types, and circuits are affected by drugs of abuse and drive behaviors characteristic of addiction, it is necessary both to observe and manipulate neural activity in addiction-related behavioral paradigms. In pursuit of this goal, there have been several key technological advancements in in vivo imaging and neural circuit modulation in recent years, which have shed light on the cellular and circuit mechanisms of addiction. Here we discuss some of these key technologies, including circuit modulation with optogenetics, in vivo imaging with miniaturized single-photon microscopy (miniscope) and fiber photometry, and how the application of these technologies has garnered novel insights into the neurobiology of addiction.

Indexed as

NeurobiologyOptogeneticsBrain

Identifiers

PMID34145393
PMCPMC9190069

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.