ArticleScientific reports2021
A rapid phenotype change in the pathogen Perkinsus marinus was associated with a historically significant marine disease emergence in the eastern oyster.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 30 citations in OpenAlex.
- Range-Wide Genetic Population Structure and Environmental Adaptation in the Eastern Oyster (Crassostrea virginica) Provides Insight for Aquaculture.Molecular ecology · 2026Article
- Drivers ofParasitology · 2026Article
- Effect of Natural Perkinsus Olseni Infection Abundance on the Lipid Metabolism in the Gills of Manila Clam (Ruditapes philippinarum).Marine biotechnology (New York, N.Y.) · 2025Article
- A suite of ddPCR assays targeting microbial pathogens for improved management of shellfish aquaculture.Applied and environmental microbiology · 2025Article
- High parasite prevalence in an ecosystem engineer correlated with both local- and landscape-level factors.Oecologia · 2024Article
- Article
- Into the danger zone: How the within-host distribution of parasites controls virulence.Ecology letters · 2024Article
- Morphological and functional characterization of the oysterFish and shellfish immunology reports · 2023Article
- Host genetic identity determines parasite community structure across time and space in oyster restoration.Proceedings. Biological sciences · 2023Article
- A reconstruction of parasite burden reveals one century of climate-associated parasite decline.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Development of a novel electroporation method for the oyster parasite Perkinsus marinus.Scientific reports · 2022Article
- Disease-driven mass mortality event leads to widespread extirpation and variable recovery potential of a marine predator across the eastern Pacific.Proceedings. Biological sciences · 2021Article
- Emerging Parasitic Protists: The Case of Perkinsea.Frontiers in microbiology · 2021Review
- Transcriptomic Response toFrontiers in genetics · 2021Article
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Authors and funding
8 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The protozoan parasite Perkinsus marinus, which causes dermo disease in Crassostrea virginica, is one of the most ecologically important and economically destructive marine pathogens. The rapid and persistent intensification of dermo in the USA in the 1980s has long been enigmatic. Attributed originally to the effects of multi-year drought, climatic factors fail to fully explain the geographic extent of dermo's intensification or the persistence of its intensified activity. Here we show that emergence of a unique, hypervirulent P. marinus phenotype was associated with the increase in prevalence and intensity of this disease and associated mortality. Retrospective histopathology of 8355 archival oysters from 1960 to 2018 spanning Chesapeake Bay, South Carolina, and New Jersey revealed that a new parasite phenotype emerged between 1983 and 1990, concurrent with major historical dermo disease outbreaks. Phenotypic changes included a shortening of the parasite's life cycle and a tropism shift from deeper connective tissues to digestive epithelia. The changes are likely adaptive with regard to the reduced oyster abundance and longevity faced by P. marinus after rapid establishment of exotic pathogen Haplosporidium nelsoni in 1959. Our findings, we hypothesize, illustrate a novel ecosystem response to a marine parasite invasion: an increase in virulence in a native parasite.
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