ArticleNature communications2021
Ionic contrast across a lipid membrane for Debye length extension: towards an ultimate bioelectronic transducer.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The trial behind it
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Who cites it
15 citing papers in PubMed.
- Hydrogel Phase Transition-Driven Soft Gating Circumvents Debye Screening for Advanced Biosensing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Discriminating Between Living and Dead Bacteria With a Field-Effect Transistor Based on Nano-Channels.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Angstrom-fluidic chemical synapses for accurate cancer diagnosis.Nature communications · 2026Article
- Lipid-capped transistors bring cardiac testing closer to the bedside.National science review · 2026Article
- State-of-the-Art Applications of Field-Effect Transistor Biosensors in Exosome Detection: A Comprehensive Review.Biosensors · 2026Review
- A transistor-based point-of-care assay with lipid-capped sensory interface for clinical profiling of cardiovascular diseases.National science review · 2026Article
- All-Atomic Computational Perspectives for Understanding Morphable Electric Double Layers: A Review.Small (Weinheim an der Bergstrasse, Germany) · 2025Review
- Toward Personalized Immunotherapeutic Drug Monitoring with Multiplexed Extended-Gate Field-Effect-Transistor Biosensors.Small science · 2025Article
- Binding ofLangmuir : the ACS journal of surfaces and colloids · 2024Article
- Biomolecular sensors for advanced physiological monitoring.Nature reviews bioengineering · 2023Review
- Towards detection of biomarkers in the eye using an aptamer-based graphene affinity nanobiosensor.Talanta · 2022Article
- Peptide-DNA origami as a cryoprotectant for cell preservation.Science advances · 2022Article
- Technical Perspectives on Applications of Biologically Coupled Gate Field-Effect Transistors.Sensors (Basel, Switzerland) · 2022Article
- Graphene oxide-graphene Van der Waals heterostructure transistor biosensor for SARS-CoV-2 protein detection.Talanta · 2022Article
- Materials and Interface Designs of Waterproof Field-Effect Transistor Arrays for Detection of Neurological Biomarkers.Small (Weinheim an der Bergstrasse, Germany) · 2022Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite technological advances in biomolecule detections, evaluation of molecular interactions via potentiometric devices under ion-enriched solutions has remained a long-standing problem. To avoid severe performance degradation of bioelectronics by ionic screening effects, we cover probe surfaces of field effect transistors with a single film of the supported lipid bilayer, and realize respectable potentiometric signals from receptor-ligand bindings irrespective of ionic strength of bulky solutions by placing an ion-free water layer underneath the supported lipid bilayer. High-energy X-ray reflectometry together with the circuit analysis and molecular dynamics simulation discovered biochemical findings that effective electrical signals dominantly originated from the sub-nanoscale conformational change of lipids in the course of receptor-ligand bindings. Beyond thorough analysis on the underlying mechanism at the molecular level, the proposed supported lipid bilayer-field effect transistor platform ensures the world-record level of sensitivity in molecular detection with excellent reproducibility regardless of molecular charges and environmental ionic conditions.
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