ArticleNature communications2021
Nickel-catalysed migratory hydroalkynylation and enantioselective hydroalkynylation of olefins with bromoalkynes.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Enantio- and regioselective nickel/photoredox-catalyzed cross-electrophile coupling of benzylic aziridines with alkynyl bromides.Science advances · 2026Article
- Syntheses of 2,2'-dihalo-1,1'-binaphthyl compounds via palladium-catalysed 1,2-halo shift-cyclisation coupling reaction of α-hydroxyl haloalkynes.Nature communications · 2026Article
- Stereodivergent synthesis of chiral amines bearing vicinal stereocenters via hydroamination of trisubstituted alkenes.Nature communications · 2026Article
- Stereodivergent construction of non-adjacent stereocentres via migratory functionalization of alkenes.Nature chemistry · 2026Article
- Noncovalent interaction-driven regio- and enantioselective hydroalkynylation of unactivated alkenes to access remote chiral nitriles.Science advances · 2025Article
- Regiocontrolled hydrobromination of unactivated alkenes via direct and chain-walking pathways.Science advances · 2025Article
- Cobalt(0)-Catalyzed Isomerization of Allylamines Promoted by Monodentate Benzofuran Phosphines.Journal of the American Chemical Society · 2025Article
- Base-Catalyzed Remote Hydrogermylation of Olefins.Angewandte Chemie (International ed. in English) · 2025Article
- Rapid assembly of enantioenriched α-arylated ketones via Ni-catalyzed asymmetric cross-hydrocarbonylation enabled by alkene sorting.Nature communications · 2025Article
- Ligand Relay Catalysis Enables Asymmetric Migratory Hydroarylation for the Concise Synthesis of Chiral α-(Hetero)Aryl-Substituted Amines.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Immobilization of Trifluoromethyl-Substituted Pyridine-Oxazoline Ligand and Its Application in Asymmetric Continuous Flow Synthesis of Benzosultams.The Journal of organic chemistry · 2023Article
- Recent Progress in NiH-Catalyzed Linear or Branch Hydrofunctionalization of Terminal or Internal Alkenes.Topics in current chemistry (Cham) · 2023Review
- Enantioselective Hydroalkenylation and Hydroalkynylation of Alkenes Enabled by a Transient Directing Group: Catalyst Generality through Rigidification.Angewandte Chemie (International ed. in English) · 2023Article
- Enantioselective synthesis of N-alkylindoles enabled by nickel-catalyzed C-C coupling.Nature communications · 2022Article
- Access to dialkylated allylic stereogenic centers by Ni-catalysed enantioselective hydrovinylation of unactivated alkenes.Chemical science · 2022Article
- Enantioselective synthesis of α-aminoboronates by NiH-catalysed asymmetric hydroamidation of alkenyl boronates.Nature communications · 2022Article
- Enantioselective and Diastereodivergent Allylation of Propargylic C-H Bonds.Journal of the American Chemical Society · 2022Article
- Regio- and enantioselective remote hydroarylation using a ligand-relay strategy.Nature communications · 2022Article
- Air-Stable PdAngewandte Chemie (International ed. in English) · 2022Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
α-Chiral alkyne is a key structural element of many bioactive compounds, chemical probes, and functional materials, and is a valuable synthon in organic synthesis. Here we report a NiH-catalysed reductive migratory hydroalkynylation of olefins with bromoalkynes that delivers the corresponding benzylic alkynylation products in high yields with excellent regioselectivities. Catalytic enantioselective hydroalkynylation of styrenes has also been realized using a simple chiral PyrOx ligand. The obtained enantioenriched benzylic alkynes are versatile synthetic intermediates and can be readily transformed into synthetically useful chiral synthons.
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