Evidence map›Paper›PMID 34145255›Full record

ArticleNature communications2021

Measurement of lipogenic flux by deuterium resolved mass spectrometry.

Xiaorong Fu, Stanisław Deja, Justin A Fletcher, Norma N Anderson, Monika Mizerska, Gonçalo Vale, Jeffrey D Browning, Jay D Horton, Jeffrey G McDonald, Matthew A Mitsche and 1 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 35 citations in OpenAlex.

  1. ACS central science · 2026
    Article
  2. Observational
  3. Review
  4. A Stable Isotope Tracing Primer for the Mass Spectrometrist.Annual review of analytical chemistry (Palo Alto, Calif.) · 2026
    Review
  5. Article
  6. Review
  7. Turnover Rate of Lipids, Metabolites and Proteins Revealed by 156-Day-Long DInternational journal of molecular sciences · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Widespread discordance between mRNA expression, protein abundance andbioRxiv : the preprint server for biology · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Untargeted Lipidomics after DInternational journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Xiaorong FuCenter for Human Nutrition, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-8042-4206
Stanisław DejaCenter for Human Nutrition, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-7714-2547
Justin A FletcherCenter for Human Nutrition, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Norma N AndersonCenter for Human Nutrition, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Monika MizerskaCenter for Human Nutrition, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Gonçalo ValeCenter for Human Nutrition, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Jeffrey D BrowningDepartment of Clinical Nutrition, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Jay D HortonCenter for Human Nutrition, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Jeffrey G McDonaldCenter for Human Nutrition, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0003-1570-4142
Matthew A MitscheCenter for Human Nutrition, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Shawn C BurgessCenter for Human Nutrition, The University of Texas Southwestern Medical Center, Dallas, TX, USA. shawn.burgess@utsouthwestern.edu.ORCID 0000-0002-9586-5511
The University of Texas Southwestern Medical Center · USSouthwestern Medical Center · US

Funding

TR&D 3: Imaging Carbohydrate MetabolismP41EB015908 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI MALLOY, CRAIG R · 2012 to 2021
$10.9M
Factors controlling metabolic flux in the liver - Supplement RevisionR01DK078184 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Shawn C Burgess · 2008 to 2026
$6.8M
Measuring Lipid Flux By Ultra High Resolution Mass SpectrometryR35GM137991 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI MITSCHE, MATTHEW ALVIN · 2020 to 2024
$2.2M
Regulation of lipogenesis by TCA cycle metabolismR01DK128168 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI BURGESS, SHAWN C · 2021 to 2025
$2.1M
NIBIB NIH HHS P41 EB015908NIDDK NIH HHS R01 DK078184NIDDK NIH HHS R01 DK128168NIGMS NIH HHS R35 GM137991
6 · The paper itself

Abstract

De novo lipogenesis (DNL) is disrupted in a wide range of human disease. Thus, quantification of DNL may provide insight into mechanisms and guide interventions if it can be performed rapidly and noninvasively. DNL flux is commonly measured by

Indexed as

AnimalsDeuteriumFatty AcidsGas Chromatography-Mass SpectrometryLipogenesisLiverMaleMiceMice, Inbred C57BLTriglyceridesDeuteriumFatty AcidsTriglycerides

Identifiers

PMID34145255
PMCPMC8213799
OpenAlexW3170001590

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.