ArticleNature communications2021
Olfactory expression of trace amine-associated receptors requires cooperative cis-acting enhancers.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- A spatial code governs olfactory receptor choice and aligns sensory maps in the nose and brain.Cell · 2026Article
- Vertebrate-wide transcriptomic screening identifies immune cell-specific expression of the conserved OR-κ gene.Zoological letters · 2026Article
- An epigenetic repressor TRIM66 dictates monogenic olfactory receptor expression, neural activity, and olfactory behavior.Nature communications · 2025Article
- A common mechanism of singular gene choice is revealed by broadly expressed odorant receptor transgenes within the olfactory epithelium.Cell reports · 2025Article
- Chemosensory Receptors in Vertebrates: Structure and Computational Modeling Insights.International journal of molecular sciences · 2025Review
- Determinants of odorant receptor transcription and gene choice.Chemical senses · 2025Review
- Toward discovering a novel family of peptides targeting neuroinflammatory states of brain microglia and astrocytes.Journal of neurochemistry · 2024Article
- Establishment and maintenance of random monoallelic expression.Development (Cambridge, England) · 2024Review
- Epigenetic programming of stochastic olfactory receptor choice.Genesis (New York, N.Y. : 2000) · 2024Review
- Activity-dependent formation of the topographic map and the critical period in the development of mammalian olfactory system.Genesis (New York, N.Y. : 2000) · 2024Review
- Evolution of Brain-Expressed Biogenic Amine Receptors into Olfactory Trace Amine-Associated Receptors.Molecular biology and evolution · 2022Article
- Functional analysis of human olfactory receptors with a high basal activity using LNCaP cell line.PloS one · 2022Article
- Coordination of two enhancers drives expression of olfactory trace amine-associated receptors.Nature communications · 2021Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Olfactory sensory neurons express a large family of odorant receptors (ORs) and a small family of trace amine-associated receptors (TAARs). While both families are subject to so-called singular expression (expression of one allele of one gene), the mechanisms underlying TAAR gene choice remain obscure. Here, we report the identification of two conserved sequence elements in the mouse TAAR cluster (T-elements) that are required for TAAR gene expression. We observed that cell-type-specific expression of a TAAR-derived transgene required either T-element. Moreover, deleting either element reduced or abolished expression of a subset of TAAR genes, while deleting both elements abolished olfactory expression of all TAARs in cis with the mutation. The T-elements exhibit several features of known OR enhancers but also contain highly conserved, unique sequence motifs. Our data demonstrate that TAAR gene expression requires two cooperative cis-acting enhancers and suggest that ORs and TAARs share similar mechanisms of singular expression.
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