Evidence map›Paper›PMID 34144978›Full record

ArticleScience advances2021

Two mechanisms of chromosome fragility at replication-termination sites in bacteria.

Qian Mei, Devon M Fitzgerald, Jingjing Liu, Jun Xia, John P Pribis, Yin Zhai, Ralf B Nehring, Jacob Paiano, Heyuan Li, Andre Nussenzweig and 2 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 23 citations in OpenAlex.

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  18. Delineation of the Ancestral Tus-Dependent Replication Fork Trap.International journal of molecular sciences · 2021
    Article
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Qian MeiDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0003-4648-7232
Devon M FitzgeraldDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-2480-7269
Jingjing LiuDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Jun XiaDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
John P PribisDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-9267-6715
Yin ZhaiDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Ralf B NehringDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0001-5156-7734
Jacob PaianoLaboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD 20892, USA.ORCID 0000-0001-6116-8067
Heyuan LiDepartment of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Andre NussenzweigLaboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
P J HastingsDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Susan M RosenbergDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA. smr@bcm.edu.ORCID 0000-0003-1444-473X
Baylor College of Medicine · USNational Cancer Institute · US

Funding

DNA RepairZIABC010283 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI NUSSENZWEIG, ANDRE A. · 2009 to 2025
$27.0M
Relationship between DNA damage detection and signalingZIABC010959 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI NUSSENZWEIG, ANDRE A. · 2009 to 2025
$27.0M
Harnessing Proteins as Drugs: the Protectome of Cancer- and Aging-Prevention ProteinsDP1AG072751 · NIA · BAYLOR COLLEGE OF MEDICINE · PI ROSENBERG, SUSAN M · 2020 to 2024
$5.6M
Mechanisms of Endogenous DNA Damage PromotionR01CA250905 · NCI · BAYLOR COLLEGE OF MEDICINE · PI MILLER, KYLE M, ROSENBERG, SUSAN M · 2020 to 2024
$3.3M
MUTATIONAL SIGNATURE(S) OF HUMAN GENOMIC REARRANGEMENT MECHANISMSR01GM106373 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI HASTINGS, PHILIP JOHN, LUPSKI, JAMES R. · 2014 to 2022
$3.1M
MOLECULAR MECHANISMS OF STRESS-INDUCED MUTATIONR35GM122598 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI ROSENBERG, SUSAN M · 2017 to 2020
$2.4M
Forward Genomics of Damage Control: An Undiscovered Class of Cancer GenesDP1CA174424 · NCI · BAYLOR COLLEGE OF MEDICINE · PI ROSENBERG, SUSAN M · 2012 to 2013
$1.5M
NCI NIH HHS DP1 CA174424NCI NIH HHS R01 CA250905NIA NIH HHS DP1 AG072751NIGMS NIH HHS R01 GM106373NIGMS NIH HHS R35 GM122598
6 · The paper itself

Abstract

Chromosomal fragile sites are implicated in promoting genome instability, which drives cancers and neurological diseases. Yet, the causes and mechanisms of chromosome fragility remain speculative. Here, we identify three spontaneous fragile sites in the

Indexed as

Chromosome FragilityNeoplasmsDNADNA, CruciformDNA ReplicationEscherichia coliGenomic InstabilityHumansDNADNA, Cruciform

Identifiers

PMID34144978
PMCPMC8213236
OpenAlexW3170550153

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.