Evidence map›Paper›PMID 34144845›Full record

ArticleTrends in neurosciences2021

Distinct globus pallidus circuits regulate motor and cognitive functions.

Asier Aristieta, Aryn Gittis

Abstract readComment
In one paragraph

Article in Trends in neurosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  10. Atrophy in subcortical gray matter in adult patients with moyamoya disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Asier AristietaDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, USA; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA, USA.
Aryn GittisDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, USA; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA, USA. Electronic address: agittis@cmu.edu.

Funding

Circuit-Inspired Strategies to Restore Basal Ganglia Function in Mouse Models of Parkinson’s DiseaseR35NS132213 · NINDS · CARNEGIE-MELLON UNIVERSITY · PI Aryn Hilary Gittis · 2023 to 2026
$2.8M
DBS Protocols for Long-Lasting Therapeutic Benefit in Mouse and Primate Models of Parkinson's DiseaseR01NS117058 · NINDS · CARNEGIE-MELLON UNIVERSITY · PI GITTIS, ARYN HILARY, TURNER, ROBERT STERLING · 2020 to 2024
$2.8M
DELINEATING CELL-SPECIFIC OUTPUT PATHWAYS OF THE GPe THAT SUPPORT LONG-LASTING BEHAVIORAL RECOVERY IN DOPAMINE DEPLETED MICER01NS104835 · NINDS · CARNEGIE-MELLON UNIVERSITY · PI GITTIS, ARYN HILARY · 2018 to 2022
$1.9M
CIRCUIT MECHANISMS UNDERLYING LONG-LASTING RECOVERY OF MOVEMENT IN DOPAMINE DPELETED MICE INDUCED BY OPTOGENETIC INTERVENTION IN THE GPeR01NS101016 · NINDS · CARNEGIE-MELLON UNIVERSITY · PI GITTIS, ARYN HILARY · 2018 to 2022
$1.7M
NINDS NIH HHS R01 NS101016NINDS NIH HHS R01 NS104835NINDS NIH HHS R01 NS117058NINDS NIH HHS R35 NS132213
6 · The paper itself

Abstract

A recent article by Lilascharoen et al. identified two distinct pathways in the globus pallidus (GPe) that are associated with discrete behaviors. Dysfunctions in these pathways were shown to underlie Parkinsonian motor and cognitive deficits in mice, and selective manipulation of these circuits rescued locomotor deficits and improved behavioral flexibility.

Indexed as

Globus PallidusNeuronsAnimalsCognitionMicecognitive functionexternal segment of the globus pallidus (GPe)locomotionParkinson's diseaseparvalbuminreversal learning

Identifiers

PMID34144845
PMCPMC8562495

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.