Evidence map›Paper›PMID 34144781›Full record

GuidelineESMO open2021

Cancer cachexia in adult patients: ESMO Clinical Practice Guidelines

J Arends, F Strasser, S Gonella, T S Solheim, C Madeddu, P Ravasco, L Buonaccorso, M A E de van der Schueren, C Baldwin, M Chasen and 2 more

Erratum issued Registry-linked trialAbstract readPractice Guideline
In one paragraph

Guideline in ESMO open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT06517199 (Randomized Placebo-controlled Study of Olanzapine for Cancer Related Anorexia-cachexia Syndrome), which is not on this map. Cited by 281 papers, 24 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
281citing papers in PubMed, 24 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06517199 phase3unknown statusnot on this mapstarted 2024, after this paper: background citation

Randomized Placebo-controlled Study of Olanzapine for Cancer Related Anorexia-cachexia Syndrome

TypeinterventionalSponsorMahidol UniversityRan2024 to 2026Enrolled138ConditionsAnorexia, CachexiaArmsOlanzapine 2.5 MG, Olanzapine 5 MG, Placebo
3 · Its place in the literature

Who cites it

281 citing papers in PubMed, 24 syntheses or guidelines pooled it.

  1. Association between cancer cachexia and treatment-related adverse outcomes in patients with gastrointestinal cancers: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
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  5. Comparison of EPA and DHA&EPA on body weight, BMI, and lean body mass in cancer patients: a network meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Pooled it
  6. Guideline
  7. Pooled it
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  11. Multimodal interventions for cachexia management.The Cochrane database of systematic reviews · 2025
    Pooled it
  12. The effects of enteral tube feeding on nutrition, survival, and quality of life outcomes in advanced upper gastrointestinal cancers: a systematic literature review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Pooled it
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  17. SEOM clinical guidelines for cancer anorexia-cachexia syndrome (2023).Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Guideline
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  20. Guideline

221 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

J ArendsDepartment of Medicine I, Medical Center - University of Freiburg Faculty of Medicine, University of Freiburg, Freiburg, Germany.
F StrasserIntegrated Cancer Rehabilitation and Cancer Fatigue Clinic, Klinik Gais/Kliniken Valens; Clinic Medical Oncology and Hematology, Cantonal Hospital St Gallen, St Gallen, Switzerland.
S GonellaDirection of Health Professions, Azienda Ospedaliero Universitaria Città della Salute e della Scienza of Turin, University of Turin, Turin, Italy; Department of Public Health and Pediatrics, University of Turin, Turin, Italy.
T S SolheimDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; Cancer Clinic, Trondheim University Hospital, Trondheim, Norway.
C MadedduMedical Oncology Unit, Azienda Ospedaliero Universitaria Cagliari, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
P RavascoImmuno-Hemotherapy and Oncology, University Hospital of Santa Maria, CHULN, Lisbon, Portugal; Center for Interdisciplinary Research in Health, Universidade Católica Portuguesa, Lisbon, Portugal; University of Lisbon, Portugal.
L BuonaccorsoPsycho-Oncology Unit, Azienda USL-IRCCS, Reggio Emilia, Italy.
M A E de van der SchuerenDepartment of Nutrition, Dietetics and Life Style, School of Allied Health, HAN University of Applied Sciences, Nijmegen, The Netherlands; Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands.
C BaldwinDepartment of Nutritional Sciences, King's College London, London, UK.
M ChasenDepartment of Medicine, University of Toronto, Toronto, Canada; Department of Family Medicine, McMaster University, Hamilton, Canada; William Osler Health Services, Brampton, Canada.
C I RipamontiOncology-Supportive Care in Cancer Unit, Department of Onco-Haematology, Fondazione IRCCS Istituto Nazionale dei Tumori Milano, Milan, Italy.
ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CachexiaNeoplasmsAdultHumansassessmentcachexiacancerClinical Practice Guidelinesnutritiontreatment

Identifiers

PMID34144781
PMCPMC8233663

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.