ReviewSeminars in vascular surgery2021
A review of acute limb ischemia in COVID-positive patients.
Review in Seminars in vascular surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 26 citations in OpenAlex.
- A rare complication of acute lower limb ischemia post coronavirus disease 2019 infection in a healthy pediatric patient: case report.BMC pediatrics · 2023Article
- An extremely rare cause of flank pain: Answers.Pediatric nephrology (Berlin, Germany) · 2023Article
- Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies.Acta pharmacologica Sinica · 2023Review
- COVID-associated acute limb ischemia during the Delta surge and the effect of vaccines.Journal of vascular surgery · 2023Article
- Unexpected arterial thrombosis and acute limb ischemia in a young male patient with COVID-19: A case report.Frontiers in surgery · 2023Article
- Article
- Management of Acute Limb Ischaemia Due to COVID-19 Induced Arterial Thrombosis: A Multi-Centre Indian Experience.Annals of vascular diseases · 2022Article
- Distal arteriovenous fistula to preserve patency in COVID-19-associated acute limb ischemia.Seminars in vascular surgery · 2021Article
Corrections and comments
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Authors and funding
9 authors at 8 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This literature review discusses the current evidence on acute limb ischemia (ALI) in patients with COVID-19. Throughout the pandemic, these patients have been at increased risk of arterial thrombotic events and subsequent mortality as a result of a hypercoagulable state. The exact mechanism of thrombosis is unknown; however arterial thrombosis may be due to invasion of endothelial cells via angiotensin-converting enzyme 2 (ACE2) receptors, endothelial injury from inflammation, or even free-floating aortic thrombus. Multiple studies have been performed evaluating the medical and surgical management of these patients; the decision to proceed with operative intervention is dependent on the patient's clinical status as it relates to COVID-19 and morbidity of that disease. The interventions afforded typically include anticoagulation in patients undergoing palliation; alternatively, thrombectomy (endovascular and open) is utilized in other patients. There is a high risk of rethrombosis, despite anticoagulation, given persistent endothelial injury from the virus. Postoperative mortality can be high in these patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.