ArticleNutrition & metabolism2021
Estradiol regulates intestinal ABCG2 to promote urate excretion via the PI3K/Akt pathway.
Article in Nutrition & metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 52 citations in OpenAlex.
- Pharmacokinetics and Safety of Estradiol Valerate Tablet and Its Generic: A Phase 1 Bioequivalence Study in Healthy Chinese Postmenopausal Female Subjects.Drug design, development and therapy · 2024Trial
- Premature coronary artery disease in women: sex-specific risk factors, pathogenetic mechanisms and clinical implications.Annals of medicine · 2026Review
- ABCG2 transporter: Structural and functional associations with gout (Review).International journal of molecular medicine · 2026Review
- Prevalence of Asymptomatic Hyperuricemia and Associated Factors in Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study in Southern Vietnam.Diagnostics (Basel, Switzerland) · 2026Article
- Development and validation of a risk models for gout in patients with diabetic kidney disease.BMC endocrine disorders · 2026Article
- Urinary phytoestrogens and hyperuricemia risk in a nationally representative population: an effect modified by smoking status.Scientific reports · 2026Article
- Gender differences in asymptomatic hyperuricemia's effects on left ventricular function and remodeling in hypertension: insights from cardiac MRI.BMC cardiovascular disorders · 2026Article
- Inverted U-Shaped Association Between Serum Uric Acid and Handgrip Strength in Chinese Community-Dwelling Adults: A Repeated-Measures Cohort Study.Biomedicines · 2026Article
- Sex-related molecular phenotypes in anxiety-depressive disorders: a machine learning analysis of routine blood biomarkers.Frontiers in psychiatry · 2026Article
- Comparative associations of immune-inflammatory, immune-lipid, and metabolic composite indices with hyperuricemia among Chinese adults with glycemic abnormalities: a health examination-based cross-sectional study.Frontiers in endocrinology · 2026Observational
- Article
- Genetic Association Between Sex Hormones, Serum Urate, and Gout: A Comprehensive Mendelian Randomization Study.International journal of endocrinology · 2026Article
- Mild Hyperuricemia Attenuates Salt-Sensitive Hypertension and Kidney Damage.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Multiple comorbidities and economic burden of hospitalized gout patients in Guangdong Province.Clinical rheumatology · 2025Article
- The association between the uric acid to high-density lipoprotein cholesterol ratio (UHR) index and obesity in postmenopausal women: a cross-sectional analysis based on the NHANES.Lipids in health and disease · 2025Article
- The effect of intensive resistance exercise and excessive fructose intake on metabolic and physiological responses.Nutrition & metabolism · 2025Article
- Transcriptome-based analysis reveals relationship between duck eggshell color and eggshell strength.BMC genomics · 2025Article
- Excess Weight Loss at 6 Months Following Laparoscopic Sleeve Gastrectomy Correlates with the Remission of Hyperuricemia.Obesity surgery · 2025Article
- Association Between TyG-BMI Index and Hyperuricemia in Adult Women.Endocrinology, diabetes & metabolism · 2025Article
- The impact of serum uric acid on biological aging and mortality risk: insights from the NHANES and CHARLS cohorts.Frontiers in nutrition · 2025Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesThe study of sex differences in hyperuricemia can provide not only a theoretical basis for this clinical phenomenon but also new therapeutic targets for urate-lowering therapy. In the current study, we aimed to confirm that estradiol can promote intestinal ATP binding cassette subfamily G member 2 (ABCG2) expression to increase urate excretion through the PI3K/Akt pathway.
methodsThe estradiol levels of hyperuricemia/gout patients and healthy controls were compared, and a hyperuricemia mouse model was used to observe the urate-lowering effect of estradiol and the changes in ABCG2 expression in the kidney and intestine. In vivo and in vitro intestinal urate transport models were established to verify the urate transport function regulated by estradiol. The molecular pathway by which estradiol regulates ABCG2 expression in intestinal cells was explored.
resultsThe estradiol level of hyperuricemia/gout patients was significantly lower than that of healthy controls. Administering estradiol benzoate (EB) to both male hyperuricemic mice and female mice after removing the ovaries confirmed the urate-lowering effect of estradiol, and hyperuricemia and estradiol upregulated the expression of intestinal ABCG2. Estradiol has been confirmed to promote urate transport by upregulating ABCG2 expression in intestinal urate excretion models in vivo and in vitro. Estradiol regulates the expression of intestinal ABCG2 through the PI3K/Akt pathway.
conclusionOur study revealed that estradiol regulates intestinal ABCG2 through the PI3K/Akt pathway to promote urate excretion, thereby reducing serum urate levels.
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