Trial reportBMC musculoskeletal disorders2021
The effects of different accumulated pressure-time integral stimuli on plantar blood flow in people with diabetes mellitus.
Trial report in BMC musculoskeletal disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The trial behind it
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Who cites it
9 citing papers in PubMed, 28 citations in OpenAlex.
- Investigating plantar soft tissue elasticity modulation using air insoles during walking.BMC musculoskeletal disorders · 2026Trial
- Measurement of plantar pressure differences in the contralateral limb when using offloading modalities for diabetic foot ulcerations.Journal of foot and ankle research · 2025Trial
- In-shoe plantar temperature, normal and shear stress relationships during gait and rest periods for people living with and without diabetes.Scientific reports · 2025Article
- Targeting oxidative damage in diabetic foot ulcers: integrative strategies involving antioxidant drugs and nanotechnologies.Burns & trauma · 2025Review
- Effect of different inner pressures of air insoles and walking durations on plantar pressure time integral.Scientific reports · 2024Article
- Plantar pressure gradient and pressure gradient angle are affected by inner pressure of air insole.Frontiers in bioengineering and biotechnology · 2024Article
- Effects of contoured insoles with different materials on plantar pressure offloading in diabetic elderly during gait.Scientific reports · 2022Article
- Effect of Long-Distance Running on Inter-segment Foot Kinematics and Ground Reaction Forces: A Preliminary Study.Frontiers in bioengineering and biotechnology · 2022Article
- Relationship Between Plantar Tissue Hardness and Plantar Pressure Distributions in People With Diabetic Peripheral Neuropathy.Frontiers in bioengineering and biotechnology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExercise, especially weight-bearing exercise (e.g. walking), may affect plantar tissue viability due to prolonged repetitive high vertical and high shear pressure stimulus on the plantar tissue, and further induce development of diabetic foot ulcers (DFUs). This study aimed to investigate the effects of different accumulated pressure-time integral (APTI) stimuli induced by walking on plantar skin blood flow (SBF) responses in people with diabetes mellitus (DM).
methodsA repeated measures design was used in this study. Two walking protocols (low APTI (73,000 kPa·s) and high APTI (73,000 × 1.5 kPa·s)) were randomly assigned to ten people with DM and twenty people without DM. The ratio of SBF measured by laser Doppler flowmetry after walking to that before (normalized SBF) was used to express the SBF responses.
resultsAfter low APTI, plantar SBF of people with DM showed a similar response to people without DM (P = 0.91). However, after high APTI, people with DM had a significantly lower plantar SBF compared to people without DM (P < 0.05). In people with DM, plantar SBF in the first 2 min after both APTI stimuli significantly decreased compared to plantar SBF before walking (P < 0.05).
conclusionsPeople with DM had a normal SBF response after low APTI walking but had an impaired SBF response after high APTI walking, which suggests that they should avoid weight-bearing physical activity with intensity more than 73,000 kPa·s and should rest for more than 2 min after weight-bearing physical activity to allow a full vasodilatory response to reduce risk of DFUs.
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