ArticleBMC infectious diseases2021
Hospital-based prospective study of pertussis in infants and close contacts in Tehran, Iran.
Article in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02983487 (Pertussis Immunization Programs in Low Income Countries), which is not on this map. Cited by 7 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pertussis Immunization Programs in Low Income Countries
Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 9 citations in OpenAlex.
- Pertussis resurgence in iran: A systematic review and meta-analysis of seroimmunity and diagnostic evidence.BMC infectious diseases · 2025Pooled it
- Burden of pertussis in infants in the Eastern Mediterranean Region and the impact of maternal vaccination: a systematic review.BMC public health · 2025Pooled it
- Factors associated with pertussis infection and suspected cases in the Aseer Region, Saudi Arabia: a retrospective cross-sectional analysis study.Frontiers in public health · 2026Article
- High circulation of pertussis in infants and close contacts in Antananarivo, the capital of Madagascar in Africa, and Cambodia in Asia.BMC infectious diseases · 2025Article
- Evaluation of Pertussis Disease in Young Infants in India: A Hospital-Based Multicentric Observational Study.Indian journal of pediatrics · 2024Observational
- High pertussis circulation among infants, children and adolescents in Abidjan, Côte d'Ivoire.PloS one · 2024Article
- [Pertussis worldwide. Vaccinating children and adults].Medecine tropicale et sante internationale · 2023Article
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Authors and funding
16 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPertussis remain a global health concern, especially in infants too young to initiate their vaccination. Effective vaccination and high coverage limit the circulation of the pathogen, yet duration of protection is limited and boosters are recommended during a lifetime. In Iran, boosters are given at 18 months and 6 years old using whole pertussis vaccines for which efficacy is not known, and pertussis surveillance is scant with only sporadic biological diagnosis. Burden of pertussis is not well understood and local data are needed.
methodsHospital-based prospective study implementing molecular laboratory testing in infants aged ≤6 months and presenting ≥5 days of cough associated to one pertussis-like symptom in Tehran. Household and non-household contact cases of positive infants were evaluated by comprehensive pertussis diagnosis (molecular testing and serology) regardless of clinical signs. Clinical evaluation and source of infection were described.
resultsA total of 247 infants and 130 contact cases were enrolled. Pertussis diagnosis result was obtained for 199 infants and 104 contact cases. Infant population was mostly < 3 months old (79.9%; 157/199) and unvaccinated (62.3%; 124/199), 20.1% (40/199) of them were confirmed having B. pertussis infection. Greater cough duration and lymphocyte counts were the only symptoms associated to positivity. Half of the contact cases (51.0%; 53/104) had a B. pertussis infection, median age was 31 years old. A proportion of 28.3% (15/53) positive contacts did not report any symptom. However, 67.9% (36/53) and 3.8% (2/53) of them reported cough at inclusion or during the study, including 20.8% (11/53) who started coughing ≥7 days before infant cough onset. Overall, only five samples were successfully cultured.
conclusionThese data evidenced the significant prevalence of pertussis infection among paucy or poorly symptomatic contacts of infants with pertussis infection. Widespread usage of molecular testing should be implemented to identify B. pertussis infections.
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