ArticleBMC plant biology2021
Multi-omics analysis of the bioactive constituents biosynthesis of glandular trichome in Perilla frutescens.
Article in BMC plant biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 63 citations in OpenAlex.
- Trichomes in Plant Defence, Development and Metabolic Integration Under Environmental Stress.Plant, cell & environment · 2026Review
- Genome-Wide Identification and Analysis of BAHD Acyltransferases Involved in Anthocyanin Biosynthesis inBiology · 2026Article
- Integrated Omic Analyses Reveal Module Networks Regulating Growth and Bioactive Component Synthesis ofPlants (Basel, Switzerland) · 2026Article
- Genome-wide analysis of PfBBXs transcription factors in Perilla frutescens and their expression responses to different light intensities.Plant molecular biology · 2025Article
- Quantitative Comparison of Yield, Quality, and Metabolic Products of Different Medicinal Parts of Two Types ofPlants (Basel, Switzerland) · 2025Article
- Comprehensive Review ofFoods (Basel, Switzerland) · 2025Review
- Rapid discrimination and quantification of chemotypes in Perillae folium using FT-NIR spectroscopy and GC-MS combined with chemometrics.Food chemistry: X · 2024Article
- Multi-omics analysis uncovers the transcriptional regulatory mechanism of magnesium Ions in the synthesis of active ingredients in Sophora tonkinensis.Scientific reports · 2024Article
- Transcriptome and metabolome analysis revealed the dynamic change of bioactive compounds of Fructus Ligustri Lucidi.BMC plant biology · 2024Article
- Effect ofFrontiers in veterinary science · 2024Article
- Metabolite profiling and transcriptomic analyses demonstrate the effects of biocontrol agents on alkaloid accumulation in Fritillaria thunbergii.BMC plant biology · 2023Article
- Applying quantitative spatial phenotypes analysis to the investigation of peltate glandular trichomes development pattern in Perilla frutescens.Plant methods · 2023Article
- The revealing of a novel double bond reductase related to perilla ketone biosynthesis in Perilla frutescens.BMC plant biology · 2023Article
- Formation mechanism of glandular trichomes involved in the synthesis and storage of terpenoids in lavender.BMC plant biology · 2023Article
- The Current Developments in Medicinal Plant Genomics Enabled the Diversification of Secondary Metabolites' Biosynthesis.International journal of molecular sciences · 2022Review
- Biological investigations on macro-morphological characteristics, polyphenolic acids, antioxidant activity ofSaudi journal of biological sciences · 2022Article
- Morphogenesis, ultrastructure, and chemical profiling of trichomes in Artemisia argyi H. Lév. & Vaniot (Asteraceae).Planta · 2022Article
- Combined transcriptomic and metabolomic analysis reveals the potential mechanism of seed germination and young seedling growth in Tamarix hispida.BMC genomics · 2022Article
- Integrated metabolomic and transcriptomic analyses reveal molecular response of anthocyanins biosynthesis in perilla to light intensity.Frontiers in plant science · 2022Article
- Comparison of Pulegone and Estragole Chemotypes Provides New Insight Into Volatile Oil Biosynthesis ofFrontiers in plant science · 2022Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPerilla frutescens (L.) Britt is a medicinal and edible plant widely cultivated in Asia. Terpenoids, flavonoids and phenolic acids are the primary source of medicinal ingredients. Glandular trichomes with multicellular structures are known as biochemical cell factories which synthesized specialized metabolites. However, there is currently limited information regarding the site and mechanism of biosynthesis of these constituents in P. frutescens. Herein, we studied morphological features of glandular trichomes, metabolic profiling and transcriptomes through different tissues.
resultsObservation of light microscopy and scanning electron microscopy indicated the presence of three distinct glandular trichome types based on their morphological features: peltate, capitate, and digitiform glandular trichomes. The oil of peltate glandular trichomes, collected by custom-made micropipettes and analyzed by LC-MS and GC-MS, contained perillaketone, isoegomaketone, and egomaketone as the major constituents which are consistent with the components of leaves. Metabolomics and transcriptomics were applied to explore the bioactive constituent biosynthesis in the leaves, stem, and root of P. frutescens. Transcriptome sequencing profiles revealed differential regulation of genes related to terpenoids, flavonoids, and phenylpropanoid biosynthesis, respectively with most genes expressed highly in leaves. The genes affecting the development of trichomes were preliminarily predicted and discussed.
conclusionsThe current study established the morphological and chemical characteristics of glandular trichome types of P. frutescens implying the bioactive constituents were mainly synthesized in peltate glandular trichomes. The genes related to bioactive constituents biosynthesis were explored via transcriptomes, which provided the basis for unraveling the biosynthesis of bioactive constituents in this popular medicinal plant.
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