Trial reportThe Journal of pediatrics2021
Acute and Chronic Placental Abnormalities in a Multicenter Cohort of Newborn Infants with Hypoxic-Ischemic Encephalopathy.
Trial report in The Journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02811263 (High-dose Erythropoietin for Asphyxia and Encephalopathy), which is not on this map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
High-dose Erythropoietin for Asphyxia and Encephalopathy
Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Chorioamnionitis and Two-Year Outcomes in Infants with Hypoxic-Ischemic Encephalopathy.The Journal of pediatrics · 2025Trial
- Placental Evidence of Intrauterine Stress: Mechanisms, Timing, and Links to Perinatal Brain Injury.Journal of clinical medicine · 2026Review
- Maternal-placental timing profiles of hypoxic-ischemic insult and association with prognosis in neonatal encephalopathy.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Neonatal encephalopathy and hypoxic-ischemic encephalopathy: the state of the art.Pediatric research · 2025Review
- Neonatal encephalopathy due to suspected hypoxic-ischaemic encephalopathy.World journal of pediatrics : WJP · 2025Article
- Placental histology for infants with hypoxic ischaemic encephalopathy compared with healthy controls: a case-control study.BMC pediatrics · 2025Article
- Placental inflammatory response and association with the severity of neonatal hypoxic ischemic encephalopathy.Early human development · 2025Article
- Review
- Systematic, prospective collection of placental specimens is crucial for future studies on the maternal-placental-fetal triad in neonatal encephalopathy.Pediatric research · 2024Article
- Understanding the role of the placenta in neonatal encephalopathy and outcome.Pediatric research · 2024Article
- The importance of not increasing confusion around neonatal encephalopathy and hypoxic-ischemic encephalopathy.Pediatric research · 2024Article
- Neonatal encephalopathy and hypoxic-ischemic encephalopathy: moving from controversy to consensus definitions and subclassification.Pediatric research · 2023Article
- The impact of placental genomic risk for schizophrenia and birth asphyxia on brain development.Translational psychiatry · 2023Article
- The association of placental pathology and neurodevelopmental outcomes in patients with neonatal encephalopathy.Pediatric research · 2023Article
- Placental pathology associated with lenticulostriate vasculopathy (LSV) in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2023Review
- Placental Histologic Abnormalities and 2-Year Outcomes in Neonatal Hypoxic-Ischemic Encephalopathy.Neonatology · 2023Article
- Leveraging the placenta to advance neonatal care.Frontiers in pediatrics · 2023Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 19 institutions in 1 country.
Funding
Abstract
objectiveTo examine the frequency of placental abnormalities in a multicenter cohort of newborn infants with hypoxic-ischemic encephalopathy (HIE) and to determine the association between acuity of placental abnormalities and clinical characteristics of HIE. STUDY
designInfants born at ≥36 weeks of gestation (n = 500) with moderate or severe HIE were enrolled in the High-dose Erythropoietin for Asphyxia and Encephalopathy Trial. A placental pathologist blinded to clinical information reviewed clinical pathology reports to determine the presence of acute and chronic placental abnormalities using a standard classification system.
resultsComplete placental pathologic examination was available for 321 of 500 (64%) trial participants. Placental abnormalities were identified in 273 of 321 (85%) and were more common in infants ≥40 weeks of gestation (93% vs 81%, P = .01). A combination of acute and chronic placental abnormalities (43%) was more common than either acute (20%) or chronic (21%) abnormalities alone. Acute abnormalities included meconium staining of the placenta (41%) and histologic chorioamnionitis (39%). Chronic abnormalities included maternal vascular malperfusion (25%), villitis of unknown etiology (8%), and fetal vascular malperfusion (6%). Infants with chronic placental abnormalities exhibited a greater mean base deficit at birth (-15.9 vs -14.3, P = .049) than those without such abnormalities. Patients with HIE and acute placental lesions had older mean gestational ages (39.1 vs 38.0, P < .001) and greater rates of clinically diagnosed chorioamnionitis (25% vs 2%, P < .001) than those without acute abnormalities.
conclusionsCombined acute and chronic placental abnormalities were common in this cohort of infants with HIE, underscoring the complex causal pathways of HIE.
trial registrationClinicalTrials.gov: NCT02811263.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.