Observational studyPloS one2021
Use of hyperbaric oxygen therapy for preventing delayed neurological sequelae in patients with carbon monoxide poisoning: A multicenter, prospective, observational study in Japan.
Observational study in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Temporal Changes in Diagnostic Composition and Treatment Activity Among Mechanically Ventilated ICU Patients Receiving Hyperbaric Oxygen Therapy: An 11-Year Single-Centre Retrospective Study.Journal of clinical medicine · 2026Article
- Association Between the COGAS Score and Delayed Neuropsychiatric Sequelae After Acute Carbon Monoxide Poisoning.Journal of clinical medicine · 2026Article
- Study on the construction of a predictive model for delayed encephalopathy after acute carbon monoxide poisoning.BMC neurology · 2026Article
- Effect of hyperbaric oxygen therapy on early features of carbon monoxide poisoning focusing on neurological symptoms.International journal of emergency medicine · 2025Article
- Review of Hyperbaric Oxygen Therapy as an Adjunctive Intervention for Metabolic Disorders.Antioxidants (Basel, Switzerland) · 2025Review
- Analysis of factors associated with the development of delayed encephalopathy following acute carbon monoxide poisoning.Scientific reports · 2024Article
- Binding of Carbon Monoxide to Hemoglobin in an Oxygen Environment: Force Field Development for Molecular Dynamics.Journal of chemical theory and computation · 2024Article
- Early and late adverse clinical outcomes of severe carbon monoxide intoxication: A cross-sectional retrospective study.PloS one · 2024Article
- Delayed neuropsychiatric sequelae with improvement of decreased cerebral bold flow by single-photon emission computed tomography during hyperbaric oxygen therapy: A case report with a 10-year follow-up.PCN reports : psychiatry and clinical neurosciences · 2023Article
- Association between number of hyperbaric oxygen therapy sessions and neurocognitive outcomes of acute carbon monoxide poisoning.Frontiers in medicine · 2023Article
- Multi-Modal Synergistic 99mTc-TRODAT-1 SPECT and MRI for Evaluation of the Efficacy of Hyperbaric Oxygen Therapy in CO-Induced Delayed Parkinsonian and Non-Parkinsonian Syndromes.Antioxidants (Basel, Switzerland) · 2022Article
- A New Phased-Array Magnetic Resonance Imaging Receive-Only Coil for HBO2 Studies.Sensors (Basel, Switzerland) · 2022Article
- Should We Use Hyperbaric Oxygen for Carbon Monoxide Poisoning Management? A Network Meta-Analysis of Randomized Controlled Trials.Healthcare (Basel, Switzerland) · 2022Article
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Authors and funding
12 authors at 9 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe purpose of this study was to clarify the practical clinical treatment for acute carbon monoxide (CO) poisoning in Japan and to investigate the efficacy of hyperbaric oxygen (HBO2) therapy in preventing delayed neurological sequelae (DNS) in the acute phase of CO poisoning.
methodsWe conducted a multicenter, prospective, observational study of acute CO poisoning in Japan. Patients with acute CO poisoning were enrolled and their treatment details were recorded. The primary endpoint was the onset of DNS within 2 months of CO exposure. Factors associated with DNS were assessed with logistic regression analysis.
resultsA total of 311 patients from 57 institutions were registered and 255 were analyzed: 171 received HBO2 therapy (HBO2 group) and 84 did not (normobaric oxygen [NBO2] group). HBO2 therapy was performed zero, once, twice, or three times within the first 24 h in 1.8%, 55.9%, 30.9%, and 11.3% of the HBO2 group, respectively. The treatment pressure in the first HBO2 session was 2.8 ATA (47.9% of the HBO2 group), 2.0 ATA (41.8%), 2.5 ATA (7.9%), or another pressure (2.4%). The incidence of DNS was 13/171 (7.6%) in the HBO2 group and 3/84 (3.6%) in the NBO2 group (P = 0.212). The number of HBO2 sessions in the first 24 h was one of the factors associated with the incidence of DNS (odds ratio, 2.082; 95% confidence interval, 1.101-3.937; P = 0.024).
conclusionsThe practical clinical treatment for acute CO poisoning, including HBO2 therapy, varied among the institutions participating in Japan. HBO2 therapy with inconsistent protocols showed no advantage over NBO2 therapy in preventing DNS. Multiple HBO2 sessions was associated with the incidence of DNS.
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