Evidence map›Paper›PMID 34143837›Full record

SynthesisPloS one2021

Effect of resistance training with blood flow restriction on muscle damage markers in adults: A systematic review.

Victor Sabino de Queiros, Ísis Kelly Dos Santos, Paulo Francisco Almeida-Neto, Matheus Dantas, Ingrid Martins de França, Wouber Hérickson de Brito Vieira, Gabriel Rodrigues Neto, Paulo Moreira Silva Dantas, Breno Guilherme de Araújo Tinôco Cabral

Registry-linked trialAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05037942 (The Influence of Restriction Pressure on Indices of Exercise-Induced Muscle Damage Following Low-Load Blood Flow-Restricted Resistance Exercise), which is not on this map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05037942 nacompletednot on this map

The Influence of Restriction Pressure on Indices of Exercise-Induced Muscle Damage Following Low-Load Blood Flow-Restricted Resistance Exercise: A Randomised Controlled Trial in Healthy Adults

TypeinterventionalSponsorUniversity of SurreyRan2021 to 2022Enrolled34ConditionsMuscle Damage, Muscle Soreness, Muscle StrengthArmsBlood flow restriction at 40% limb occlusion pressure, Blood flow restriction at 80% limb occlusion pressure
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Victor Sabino de QueirosGraduate Program in Physical Education, Federal University of Rio Grande do Norte (UFRN), Natal, Rio Grande do Norte, Brazil.ORCID 0000-0003-4117-0295
Ísis Kelly Dos SantosGraduate Program in Health Sciences, Federal University of Rio Grande do Norte (UFRN), Natal, Rio Grande do Norte, Brazil.
Paulo Francisco Almeida-NetoGraduate Program in Physical Education, Federal University of Rio Grande do Norte (UFRN), Natal, Rio Grande do Norte, Brazil.
Matheus DantasGraduate Program in Physical Education, Federal University of Rio Grande do Norte (UFRN), Natal, Rio Grande do Norte, Brazil.
Ingrid Martins de FrançaGraduate Program in Physiotherapy, Federal University of Rio Grande do Norte (UFRN), Natal, Rio Grande do Norte, Brazil.
Wouber Hérickson de Brito VieiraGraduate Program in Physiotherapy, Federal University of Rio Grande do Norte (UFRN), Natal, Rio Grande do Norte, Brazil.ORCID 0000-0003-3588-5577
Gabriel Rodrigues NetoGraduate Program in Family Health, Faculties of Nursing and Medicine Nova Esperança (FACENE / FAMENE), João Pessoa, Paraíba, Brazil.
Paulo Moreira Silva DantasGraduate Program in Physical Education, Federal University of Rio Grande do Norte (UFRN), Natal, Rio Grande do Norte, Brazil.
Breno Guilherme de Araújo Tinôco CabralGraduate Program in Physical Education, Federal University of Rio Grande do Norte (UFRN), Natal, Rio Grande do Norte, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe purpose of this review was to systematically analyze the evidence regarding the occurrence of muscle damage (changes in muscle damage markers) after resistance training with blood flow restriction sessions. MATERIALS AND

methodsThis systematic review was conducted in accordance with the PRISMA recommendations. Two researchers independently and blindly searched the following electronic databases: PubMed, Scopus, Web of Science, CINAHL, LILACS and SPORTdicus. Randomized and non-randomized clinical trials which analyzed the effect of resistance training with blood flow restriction on muscle damage markers in humans were included. The risk of bias assessment was performed by two blinded and independent researchers using the RoB2 tool.

resultsA total of 21 studies involving 352 healthy participants (men, n = 301; women, n = 51) were eligible for this review. The samples in 66.6% of the studies (n = 14) were composed of untrained individuals. All included studies analyzed muscle damage using indirect markers. Most studies had more than one muscle damage marker and Delayed Onset Muscle Soreness was the measure most frequently used. The results for the occurrence of significant changes in muscle damage markers after low-load resistance training with blood flow restriction sessions were contrasting, and the use of a pre-defined repetition scheme versus muscle failure seems to be the determining point for this divergence, mainly in untrained individuals.

conclusionsIn summary, the use of sets until failure is seen to be determinant for the occurrence of significant changes in muscle damage markers after low-load resistance training with blood flow restriction sessions, especially in individuals not used to resistance exercise.

trial registrationRegister number: PROSPERO number: CRD42020177119.

Indexed as

Resistance TrainingHumansMuscle, SkeletalMuscle StrengthMyalgiaRegional Blood Flow

Identifiers

PMID34143837
PMCPMC8213181

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.