ArticlePloS one2021
Predictors of severity and mortality among patients hospitalized with COVID-19 in Rhode Island.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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15 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Asthma and COPD as co-morbidities in patients hospitalised with Covid-19 disease: a global systematic review and meta-analysis.BMC pulmonary medicine · 2023Pooled it
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- Construction and validation of a covariate-based model for district-level estimation of excess deaths due to COVID-19 in India.Journal of global health · 2024Article
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- Predictors of intensive care unit length of stay and mortality among unvaccinated COVID-19 patients in Jordan.Infection prevention in practice · 2023Article
- Acid-base imbalance as a risk factor for mortality among COVID-19 hospitalized patients.Bioscience reports · 2023Article
- Clinical and Laboratory Predictors of Mortality in Severe COVID-19 Pneumonia: A Retrospective Study from India.Thoracic research and practice · 2023Article
- Estimation of shedding time in laboratory-confirmed COVID-19 cases in South Africa: a population-based record linkage study, March-December 2020.The Pan African medical journal · 2023Article
- Developing and validating a machine learning prognostic model for alerting to imminent deterioration of hospitalized patients with COVID-19.Scientific reports · 2022Article
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- Influencing demographic characteristics, comorbidities disease, and radiologic finding on mortality due to Covid-19 in Iran.Journal of family medicine and primary care · 2022Article
- Association of renalase with clinical outcomes in hospitalized patients with COVID-19.PloS one · 2022Article
- The Use of Mebendazole in COVID-19 Patients: An Observational Retrospective Single Center Study.Advances in virology · 2022Article
- Predictors for adult COVID-19 hospitalized inpatient mortality rate in North West Ethiopia.SAGE open medicine · 2022Article
- Prevalence of comorbidities and their association with disease severity and mortality in COVID-19 patients: A systematic review and meta-analysis.Journal of multimorbidity and comorbidityReview
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Authors and funding
9 authors at 2 institutions in 1 country.
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Abstract
backgroundIn order for healthcare systems to prepare for future waves of COVID-19, an in-depth understanding of clinical predictors is essential for efficient triage of hospitalized patients.
methodsWe performed a retrospective cohort study of 259 patients admitted to our hospitals in Rhode Island to examine differences in baseline characteristics (demographics and comorbidities) as well as presenting symptoms, signs, labs, and imaging findings that predicted disease progression and in-hospital mortality.
resultsPatients with severe COVID-19 were more likely to be older (p = 0.02), Black (47.2% vs. 32.0%, p = 0.04), admitted from a nursing facility (33.0% vs. 17.9%, p = 0.006), have diabetes (53.9% vs. 30.4%, p<0.001), or have COPD (15.4% vs. 6.6%, p = 0.02). In multivariate regression, Black race (adjusted odds ratio [aOR] 2.0, 95% confidence interval [CI]: 1.1-3.9) and diabetes (aOR 2.2, 95%CI: 1.3-3.9) were independent predictors of severe disease, while older age (aOR 1.04, 95% CI: 1.01-1.07), admission from a nursing facility (aOR 2.7, 95% CI 1.1-6.7), and hematological co-morbidities predicted mortality (aOR 3.4, 95% CI 1.1-10.0). In the first 24 hours, respiratory symptoms (aOR 7.0, 95% CI: 1.4-34.1), hypoxia (aOR 19.9, 95% CI: 2.6-152.5), and hypotension (aOR 2.7, 95% CI) predicted progression to severe disease, while tachypnea (aOR 8.7, 95% CI: 1.1-71.7) and hypotension (aOR 9.0, 95% CI: 3.1-26.1) were associated with increased in-hospital mortality.
conclusionsCertain patient characteristics and clinical features can help clinicians with early identification and triage of high-risk patients during subsequent waves of COVID-19.
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