Evidence map›Paper›PMID 34143686›Full record

ArticlePediatric allergy, immunology, and pulmonology2021

Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome Manifesting as Lymphocytic Interstitial Pneumonia and Treatment-Resistant Bullous Pemphigoid.

Stine Maria Andersen, Simon Fage, Sune Leisgaard Rubak, Mette Holm, Jens Magnus Bernth Jensen, Trine Mogensen, Mette Deleuran

Open access · goldAbstract readCase Reports
In one paragraph

Article in Pediatric allergy, immunology, and pulmonology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. European S2k guidelines on management of autoimmune blistering diseases in children and adolescents.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
    Guideline
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Stine Maria AndersenDepartment of Dermatology, Aarhus University Hospital, Aarhus, Denmark.
Simon FageDepartment of Dermatology, Aarhus University Hospital, Aarhus, Denmark.
Sune Leisgaard RubakDepartment of Pediatrics and Adolescents Medicine, Aarhus University Hospital, Aarhus, Denmark.
Mette HolmDepartment of Pediatrics and Adolescents Medicine, Aarhus University Hospital, Aarhus, Denmark.
Jens Magnus Bernth JensenDepartment of Clinical Immmunology, and Aarhus University Hospital, Aarhus, Denmark.
Trine MogensenDepartment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.
Mette DeleuranDepartment of Dermatology, Aarhus University Hospital, Aarhus, Denmark.
Aarhus University Hospital · DKAarhus University · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a rare immune deficiency with a broad clinical presentation. IPEX syndrome causes dysfunctional regulatory T cells, increasing the risk of autoimmune diseases. In this case report, we describe a 7-year-old boy with lymphocytic interstitial pneumonia and bullous pemphigoid who was recently diagnosed with IPEX syndrome.

Indexed as

Lung Diseases, InterstitialPemphigoid, BullousChildDiabetes Mellitus, Type 1DiarrheaForkhead Transcription FactorsGenetic Diseases, X-LinkedHumansImmune System DiseasesMaleT-Lymphocytes, RegulatoryForkhead Transcription Factorsbullous pemphigoidIPEXlymphocytic interstitial pneumonia

Identifiers

PMID34143686
PMCPMC8329723
OpenAlexW3171657356

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.