Evidence map›Paper›PMID 34143493›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2021

Interleukin 1 beta-induced calcium signaling via TRPA1 channels promotes mitogen-activated protein kinase-dependent mesangial cell proliferation.

Hitesh Soni, Ravi Kumar, Praghalathan Kanthakumar, Adebowale Adebiyi

Open access · greenAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Non-voltage-gated CaAmerican journal of physiology. Renal physiology · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Hitesh SoniDepartment of Physiology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
Ravi KumarDepartment of Physiology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
Praghalathan KanthakumarDepartment of Physiology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
Adebowale AdebiyiDepartment of Physiology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.ORCID 0000-0002-7033-1871
University of Tennessee Health Science Center · US

Funding

Control of microvascular function by ion channelsR01HL151735 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI ADEBIYI, ADEBOWALE · 2020 to 2023
$2.0M
NHLBI NIH HHS R01 HL151735
6 · The paper itself

Abstract

Glomerular mesangial cell (GMC)-derived pleiotropic cytokine, interleukin-1 (IL-1), contributes to hypercellularity in human and experimental proliferative glomerulonephritis. IL-1 promotes mesangial proliferation and may stimulate extracellular matrix accumulation, mechanisms of which are unclear. The present study shows that the beta isoform of IL-1 (IL-1β) is a potent inducer of IL-1 type I receptor-dependent Ca

Indexed as

AnimalsCalciumCalcium SignalingCell ProliferationCells, CulturedInterleukin-1betaMesangial CellsMiceMitogen-Activated Protein KinasesPhosphorylationTRPA1 Cation ChannelCalciumIL1B protein, mouseInterleukin-1betaMitogen-Activated Protein KinasesTRPA1 Cation ChannelTrpa1 protein, mousecalcium entryinterleukin 1 betamesangial cell proliferationmitogen-activated protein kinaseTRPA1 channels

Identifiers

PMID34143493
PMCPMC8840840
OpenAlexW3166068943

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.