ArticleClinical oral investigations2022
Characterization of salivary microbiota in elderly patients with type 2 diabetes mellitus: a matched case-control study.
Article in Clinical oral investigations, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 28 citations in OpenAlex.
- Oral Microbiota and Type 2 Diabetes: Interactions, Potential Mechanisms, and Preventive Strategies.Microorganisms · 2026Review
- Comparative Analysis of Oral Microbiome in Indian Type 2 Diabetes Mellitus (T2DM) and Periodontitis Cohorts.Diseases (Basel, Switzerland) · 2026Article
- Salivary proteomics and metaproteomics identifies distinct molecular and taxonomic signatures of type-2 diabetes.Microbiome · 2025Article
- Effects of the Oral Health Promotion Program on oral health and oral microbiota changes in diabetic elderly individuals: a quasi-experimental study.BMC oral health · 2025Article
- Differences in oral microbiota associated with type 2 diabetes mellitus between the Dai and Han populations.Journal of oral microbiology · 2025Article
- Salivary microbiota and IgA responses are different in pre-diabetic individuals compared to normoglycemic controls.Frontiers in cellular and infection microbiology · 2025Article
- The Oral Microbiome in Diabetes, Arterial Hypertension, and Obesity: A Scoping Review.Advances in experimental medicine and biology · 2025Article
- Bayesian Modeling on Microbiome Data Analysis: Application to Subgingival Microbiome Study.Statistics in biosciences · 2024Article
- A comparison of oral bacteriome isolated from periodontal pockets of participants with or without diabetes mellitus in Uganda: a case control study.BMC research notes · 2024Article
- Impact of HbA1c control and type 2 diabetes mellitus exposure on the oral microbiome profile in the elderly population.Journal of oral microbiology · 2024Article
- Microbiomic insights into the oral microbiome's role in type 2 diabetes mellitus: standardizing approaches for future advancements.Frontiers in endocrinology · 2024Review
- Changes in salivary microbiota due to gastric cancer resection and its relation to gastric fluid microbiota.Scientific reports · 2023Article
- Salivary Microbiota Associated with Peripheral Microvascular Endothelial Dysfunction.Journal of atherosclerosis and thrombosis · 2023Article
- Association between Antibiotic Exposure and Type 2 Diabetes Mellitus in Middle-Aged and Older Adults.Nutrients · 2023Article
- Enrichment of Acid-Associated Microbiota in the Saliva of Type 2 Diabetes Mellitus Adults: A Systematic Review.Pathogens (Basel, Switzerland) · 2023Review
- The gut microbiota pathway mechanisms of diabetes.AMB Express · 2023Review
- Pharmacomicrobiomics and type 2 diabetes mellitus: A novel perspective towards possible treatment.Frontiers in endocrinology · 2023Review
- Recent insights of obesity-induced gut and adipose tissue dysbiosis in type 2 diabetes.Frontiers in molecular biosciences · 2023Review
- Diabetes mellitus promotes susceptibility to periodontitis-novel insight into the molecular mechanisms.Frontiers in endocrinology · 2023Review
- Can salivary microbiome become a biodetector for type-2 diabetes? Opinion for future implications and strategies.Frontiers in nutrition · 2023Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe importance of oral health in type 2 diabetes mellitus (T2DM) is widely recognized; however, oral microbiota characteristics associated with T2DM in the elderly population are not well-understood. This study was conducted to evaluate the characteristics of the salivary microbiota in elderly Japanese patients with T2DM.
methodsSaliva samples were collected from 42 elderly Japanese patients with T2DM and 42 age- and sex-matched subjects without T2DM (control). 16S ribosomal RNA metagenomic analysis and comparative analysis of both groups were performed. Random forest classification by machine learning was performed to discriminate between the salivary microbiota in the two groups.
resultsThere were significant differences in the overall salivary microbiota structure between the T2DM and control groups (beta diversity; unweighted UniFrac distances, p = 0.001; weighted UniFrac distances, p = 0.001). The phylum Firmicutes was abundant in patients with T2DM, whereas the phylum Bacteroidetes was abundant in controls. The T2DM prediction model by random forest based on salivary microbiota data was verified with a high predictive potential in five cross-validation tests (area under the curve (AUC) = 0.938 (95% CI, 0.824-1.000)).
conclusionCharacterization revealed that the salivary microbiota profile of the elderly patients with T2DM is significantly distinct from that of the controls. CLINICAL RELEVANCE: These data indicate the necessity of oral health management based on the characteristics of the salivary microbiota in elderly patients with T2DM. Our findings will contribute to future research on the development of new diagnostic and therapeutic methods for this purpose.
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