Evidence map›Paper›PMID 34143302›Full record

ReviewPediatric nephrology (Berlin, Germany)2021

The role of carnitine in maintenance dialysis therapy.

Heather A Morgans, Vimal Chadha, Bradley A Warady

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Pediatric nephrology (Berlin, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07160452 (Effect of Levocarnitine Injections on Reducing Erythropoietin-Stimulating Agent Requirements in Hemodialysis Patients With Renal Anemia), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07160452 phase4not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Effect of Levocarnitine Injections on Reducing Erythropoietin-Stimulating Agent Requirements in Hemodialysis Patients With Renal Anemia

TypeinterventionalSponsorShaikh Zayed Hospital, LahoreRan2025 to 2026Enrolled94ConditionsAnemia, Kidney Failure, End-Stage Renal Disease, Renal DialysisArmsLevocarnitine Injection, Usual ESA-Based Anemia Care
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Nutrition support for patients with renal dysfunction in the intensive care unit: A narrative review.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2025
    Review
  3. Review
  4. Article
  5. Article
  6. L-Carnitine Supplementation in the Diabetic Heart.Arquivos brasileiros de cardiologia · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Heather A MorgansDivision of Nephrology, Department of Pediatrics, Children's Mercy Kansas City, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA.
Vimal ChadhaDivision of Nephrology, Department of Pediatrics, Children's Mercy Kansas City, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA.
Bradley A WaradyDivision of Nephrology, Department of Pediatrics, Children's Mercy Kansas City, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA. bwarady@cmh.edu.ORCID http://orcid.org/0000-0003-1812-6587
University of Missouri–Kansas City · USChildren's Mercy Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carnitine metabolism and homeostasis is significantly altered in patients receiving maintenance dialysis. Current literature in the adult and pediatric dialysis populations suggest a high prevalence of carnitine deficiency, which may lead to erythropoietin-resistant anemia, cardiomyopathy, and muscle weakness. However, the results of pediatric dialysis studies are limited and have not provided the evidence necessary to support strong recommendations or guidelines pertaining to carnitine management. The characteristics and function of carnitine, the definition and consequences of deficiency, a brief overview of recent adult studies, and current studies on carnitine supplementation in pediatric hemodialysis (HD) and peritoneal dialysis (PD) populations are discussed in this review.

Indexed as

CardiomyopathiesHyperammonemiaKidney Failure, ChronicPeritoneal DialysisAdultCarnitineChildHumansRenal DialysisCarnitineAnemiaCarnitineDeficiencyHemodialysisKidney replacement therapyPeritoneal dialysisSupplementation

Identifiers

PMID34143302
OpenAlexW3166332974

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.