ArticleEuropean journal of clinical investigation2021
Performance of early risk assessment tools to predict the later development of gestational diabetes.
Article in European journal of clinical investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- First-Trimester Prediction Models Based on Maternal Characteristics for Adverse Pregnancy Outcomes: A Systematic Review and Meta-Analysis.BJOG : an international journal of obstetrics and gynaecology · 2025Pooled it
- Development and validation of a multidimensional indicator-based risk prediction model for gestational diabetes mellitus: a nested case-control study.BMC endocrine disorders · 2026Article
- Development and multicenter validation of a novel model for selective screening of gestational diabetes mellitus: the Vietnam gestational diabetes mellitus study.BMC pregnancy and childbirth · 2025Article
- The utility of early gestational OGTT and biomarkers for the development of gestational diabetes mellitus: an international prospective multicentre cohort study.Diabetologia · 2025Observational
- Article
- Diagnosis of pregnancy disorder in the first-trimester patient plasma with Raman spectroscopy and protein analysis.Bioengineering & translational medicine · 2024Article
- Biochemical Markers in the Prediction of Pregnancy Outcome in Gestational Diabetes Mellitus.Medicina (Kaunas, Lithuania) · 2024Article
- Placental IGFBP1 levels during early pregnancy and the risk of insulin resistance and gestational diabetes.Nature medicine · 2024Article
- Maternal overweight and obesity and its association with metabolic changes and fetal overgrowth in the absence of gestational diabetes mellitus: A prospective cohort study.Acta obstetricia et gynecologica Scandinavica · 2024Article
- Placental RNA sequencing implicates IGFBP1 in insulin sensitivity during pregnancy and in gestational diabetes.Research square · 2023Article
- Risk Estimation of Gestational Diabetes Mellitus in the First Trimester.The Journal of clinical endocrinology and metabolism · 2023Article
- [Gestational diabetes mellitus (Update 2023)].Wiener klinische Wochenschrift · 2023Article
- Predictive value of first-trimester GPR120 levels in gestational diabetes mellitus.Frontiers in endocrinology · 2023Article
- The impact of regional origin on the incidence of gestational diabetes mellitus in a multiethnic European cohort.Frontiers in public health · 2023Article
- New Developments, Challenges and Open Questions in Diagnosis and Treatment of Gestational Diabetes Mellitus.Journal of clinical medicine · 2022Article
- Gestational Diabetes Mellitus-Recent Literature Review.Journal of clinical medicine · 2022Review
- Performance of early risk assessment tools to predict the later development of gestational diabetes.European journal of clinical investigation · 2021Article
- Commentary: Implications of SARS-Cov-2 infection for pregnancy with diabetes: achievements and open questions for feto-maternal medicine.BMC pregnancy and childbirth · 2021Article
- Putrescine as a Novel Biomarker of Maternal Serum in First Trimester for the Prediction of Gestational Diabetes Mellitus: A Nested Case-Control Study.Frontiers in endocrinology · 2021Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral prognostic models for gestational diabetes mellitus (GDM) are provided in the literature; however, their clinical significance has not been thoroughly evaluated, especially with regard to application at early gestation and in accordance with the most recent diagnostic criteria. This external validation study aimed to assess the predictive accuracy of published risk estimation models for the later development of GDM at early pregnancy.
methodsIn this cohort study, we prospectively included 1132 pregnant women. Risk evaluation was performed before 16 + 0 weeks of gestation including a routine laboratory examination. Study participants were followed-up until delivery to assess GDM status according to the IADPSG 2010 diagnostic criteria. Fifteen clinical prediction models were calculated according to the published literature.
resultsGestational diabetes mellitus was diagnosed in 239 women, that is 21.1% of the study participants. Discrimination was assessed by the area under the ROC curve and ranged between 60.7% and 76.9%, corresponding to an acceptable accuracy. With some exceptions, calibration performance was poor as most models were developed based on older diagnostic criteria with lower prevalence and therefore tended to underestimate the risk of GDM. The highest variable importance scores were observed for history of GDM and routine laboratory parameters.
conclusionsMost prediction models showed acceptable accuracy in terms of discrimination but lacked in calibration, which was strongly dependent on study settings. Simple biochemical variables such as fasting glucose, HbA1c and triglycerides can improve risk prediction. One model consisting of clinical and laboratory parameters showed satisfactory accuracy and could be used for further investigations.
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