ArticleeLife2021
Dependency of human and murine LKB1-inactivated lung cancer on aberrant CRTC-CREB activation.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
What it found
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Who cites it
16 citing papers in PubMed, 16 citations in OpenAlex.
- Molecular insights and therapeutic implications for the tumor suppressor role of LKB1 in non-small cell lung cancer.Cancer letters · 2026Review
- Targeting LKB1-inactivated lung cancers with a stapled peptide inhibitor of the CRTC-CREB pathway.Molecular therapy. Oncology · 2026Article
- Tumor-Derived Complement C3 Overexpression in STK11-Mutant Lung Adenocarcinoma Drives Tumor Growth and Immune Checkpoint Inhibitor Resistance.Cancer immunology research · 2026Article
- Targeting CRTC2 reversesProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Targeting LKB1/STK11-mutant cancer: distinct metabolism, microenvironment, and therapeutic resistance.Trends in pharmacological sciences · 2025Review
- S-Nitrosylation of CRTC1 in Alzheimer's disease impairs CREB-dependent gene expression induced by neuronal activity.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- DNAJB1-PRKACA Fusion Drives Fibrolamellar Liver Cancer through Impaired SIK Signaling and CRTC2/p300-Mediated Transcriptional Reprogramming.Cancer discovery · 2025Article
- Regulation of Sleep Amount by CRTC1 via Transcription ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- CRTC1 enhances PD-L1-mediated tumor immunosuppression in non-small cell lung cancer via the Notch1/Akt signaling pathway.Frontiers in immunology · 2025Article
- Rab3B enhances the stabilization of DDX6 to promote lung adenocarcinoma aggressiveness.Molecular medicine (Cambridge, Mass.) · 2024Article
- DNAJB1-PRKACA fusion protein-regulated LINC00473 promotes tumor growth and alters mitochondrial fitness in fibrolamellar carcinoma.PLoS genetics · 2024Article
- Transcriptional co-activators: emerging roles in signaling pathways and potential therapeutic targets for diseases.Signal transduction and targeted therapy · 2023Review
- MHY4571, a novel diarylcyclohexanone derivative, exerts anti-cancer activity by regulating the PKA-cAMP-response element-binding protein pathway in squamous cell lung cancer.Experimental hematology & oncology · 2022Article
- Activation of the CREB Coactivator CRTC2 by Aberrant Mitogen Signaling promotes oncogenic functions in HPV16 positive head and neck cancer.Neoplasia (New York, N.Y.) · 2022Article
- LKB1: Can We Target an Hidden Target? Focus on NSCLC.Frontiers in oncology · 2022Review
- Mechanism of negative modulation of FSH signaling by salt-inducible kinases in rat granulosa cells.Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Xin ZhouDepartment of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, United States.
Jennifer W LiDepartment of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, United States.
Zirong ChenDepartment of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, United States.
Wei NiDepartment of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, United States.
Xuehui LiDepartment of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, United States.
Rongqiang YangDepartment of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, United States.
Huangxuan ShenDepartment of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, United States.
Jian LiuZhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, International Campus, Zhejiang University, Haining, China.
Francesco J DeMayoReproductive & Developmental Biology Laboratory, National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, United States.
Jianrong LuUF Health Cancer Center, Gainesville, United States.ORCID 0000-0002-4969-6040
Frederic J KayeUF Health Cancer Center, Gainesville, United States.
Lizi WuDepartment of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, United States.ORCID 0000-0002-0076-2617
University of Florida Health · USNational Institute of Environmental Health Sciences · USSun Yat-sen University · CNUniversity of Florida · US
Funding
Environmental Signaling in Reproduction and PregnancyZIAES103311 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI DEMAYO, FRANCESCO · 2016 to 2025
$30.5MSignaling and Targeting of CRTC1-MAML2 Fusion Oncoprotein in Salivary Gland TumorR01DE023641 · NIDCR · UNIVERSITY OF FLORIDA · PI Lizi Wu · 2014 to 2026
$3.3MAberrant CRTC activation as a unique vulnerability of lung cancer with LKB1 inactivationR01CA234351 · NCI · UNIVERSITY OF FLORIDA · PI WU, LIZI · 2019 to 2023
$1.7MNCI NIH HHS R01 CA234351NIDCR NIH HHS R01 DE023641
Abstract
Lung cancer with loss-of-function of the LKB1 tumor suppressor is a common aggressive subgroup with no effective therapies. LKB1
Indexed as
Lung NeoplasmsA549 CellsAMP-Activated Protein Kinase KinasesAMP-Activated Protein KinasesAnimalsCell Line, TumorCRISPR-Cas SystemsCyclic AMP Response Element-Binding ProteinGene EditingHeterograftsHumansMiceProtein Serine-Threonine KinasesTranscription FactorsTranscriptomeAMP-Activated Protein Kinase KinasesAMP-Activated Protein KinasesCREB1 protein, humanCreb1 protein, mouseCRTC1 protein, humanCrtc1 protein, mouseCyclic AMP Response Element-Binding ProteinProtein Serine-Threonine KinasesSTK11 protein, humanStk11 protein, mouseTranscription Factorscancer biologyCRTC coactivatorshumanLKB1mousenon-small cell lung cancetherapeutic target
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.