Evidence map›Paper›PMID 34142459›Full record

ArticleChemMedChem2021

In Silico Characterization of Masitinib Interaction with SARS-CoV-2 Main Protease.

Ulises Martínez-Ortega, Diego I Figueroa-Figueroa, Francisco Hernández-Luis, Rodrigo Aguayo-Ortiz

Open access · bronzeAbstract read
In one paragraph

Article in ChemMedChem, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Masitinib Inhibits Hepatitis A Virus Replication.International journal of molecular sciences · 2023
    Article
  2. Fullerenes against COVID-19: Repurposing CMolecules (Basel, Switzerland) · 2022
    Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ulises Martínez-OrtegaDepartamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Mexico City, 04510, Mexico.ORCID 0000-0002-5032-2484
Diego I Figueroa-FigueroaDepartamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Mexico City, 04510, Mexico.ORCID 0000-0002-7355-0578
Francisco Hernández-LuisDepartamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Mexico City, 04510, Mexico.ORCID 0000-0002-8724-9495
Rodrigo Aguayo-OrtizDepartamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Mexico City, 04510, Mexico.ORCID 0000-0001-9455-5397
Universidad Nacional Autónoma de México · MX

Funding

Consejo Nacional de Ciencia y Tecnología 1002365Consejo Nacional de Ciencia y Tecnología 1002367Consejo Nacional de Ciencia y Tecnología LANCAD-UNAM-DGTIC-207Consejo Nacional de Ciencia y Tecnología LANCAD-UNAM-DGTIC-398Dirección General de Cómputo y de Tecnologías de Información y ComunicaciónDirección General de Cómputo y de Tecnologías de Información y Comunicación LANCAD-UNAM-DGTIC-207Dirección General de Cómputo y de Tecnologías de Información y Comunicación LANCAD-UNAM-DGTIC-398
6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues to be a global health problem. Despite the current implementation of COVID-19 vaccination schedules, identifying effective antiviral drug treatments for this disease continues to be a priority. A recent study showed that masitinib (MST), a tyrosine kinase inhibitor, blocks the proteolytic activity of SARS-CoV-2 main protease (M

Indexed as

BenzamidesCatalytic DomainCoronavirus 3C ProteasesCysteine Proteinase InhibitorsHydrogen BondingMolecular Dynamics SimulationMutationPiperidinesProtein BindingPyridinesSARS-CoV-2Static ElectricityThiazoles3C-like proteinase, SARS-CoV-2BenzamidesCoronavirus 3C ProteasesCysteine Proteinase InhibitorsmasitinibPiperidinesPyridinesThiazolesMain proteaseMasitinibMolecular dynamicsProtonation statesSARS-CoV-2

Identifiers

PMID34142459
PMCPMC8426933
OpenAlexW3171796479

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.