ArticleJournal of endocrinological investigation2022
The single-point insulin sensitivity estimator (SPISE) index is a strong predictor of abnormal glucose metabolism in overweight/obese children: a long-term follow-up study.
Article in Journal of endocrinological investigation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Screening accuracy of Single-Point Insulin Sensitivity Estimator (SPISE) for metabolic syndrome: a systematic review and meta-analysis.BMC endocrine disorders · 2025Pooled it
- Ratio That Reveals Risk: Defining TG:HDL-C Ratio Cutoff for Insulin Resistance in Adolescents with Obesity.Children (Basel, Switzerland) · 2026Article
- Beyond MVPA minutes: physical activity phenotypes are associated with metabolic profiles in children with obesity.European journal of pediatrics · 2026Article
- Assessment of cardiometabolic risk using single point insulin sensitivity estimator (SPISE) in pediatric Bardet-Biedl Syndrome: a pilot study.Orphanet journal of rare diseases · 2026Article
- Comparative Effects of SGLT2 Inhibitors and GLP-1 Receptor Agonists on Composite Surrogate Markers of Insulin Resistance: A Real-World Study Using METS-IR and SPISE.Journal of clinical medicine · 2026Article
- Estimated glucose disposal rate outperforms conventional insulin resistance indices in predicting acute kidney injury risk among individuals with diabetes and prediabetes.Diabetology & metabolic syndrome · 2026Article
- Association of various insulin resistance surrogate markers with mortality risk in critically ill patients with ischemic stroke: a retrospective cohort study.Cardiovascular diabetology · 2026Article
- Single point insulin sensitivity estimator index and incident impaired fasting glucose in Chinese adults: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- Single-point insulin sensitivity estimator and left main and/or three-vessel disease in patients aged 45 years or older with acute coronary syndrome: findings from the CCC-ACS project.Frontiers in endocrinology · 2026Article
- Effects of Minimally Processed Red Meat within a Plant-Forward Diet on Biomarkers of Physical and Cognitive Aging: A Randomized Controlled Crossover Feeding Trial.Current developments in nutrition · 2026Article
- Insulin resistance in obese children and adolescents: from mechanisms to screening and exercise intervention.Frontiers in pediatrics · 2026Review
- Association of Cumulative Average Uric Acid to HDL Cholesterol Ratio with the Risk of Rapidly Declining Renal Function: A Retrospective Community-Based Cohort Study in Shanghai Undertaken on Elderly Subjects with Hypertension and Type 2 Diabetes Mellitus Patients.Risk management and healthcare policy · 2026Article
- Sociodemographic, Lifestyle, and Social Isolation Correlates of TyG, METS-IR, and SPISE-IR Scores in a Large Spanish Working Population.Medical sciences (Basel, Switzerland) · 2025Article
- Enhanced oral glucose tolerance test for early detection of insulin resistance and metabolic complications in children with obesity.American journal of preventive cardiology · 2025Article
- Association between SPISE and NAFLD in patients with type 2 diabetes.Frontiers in medicine · 2025Article
- Comparison of single-point insulin sensitivity estimator (SPISE) index and cognitive performance in vitamin BJournal of family medicine and primary care · 2024Article
- SPISE INDEX (Single point insulin sensitivity estimator): indicator of insulin resistance in children and adolescents with overweight and obesity.Frontiers in endocrinology · 2024Article
- Liver fibrosis is associated with impaired bone mineralization and microstructure in obese individuals with non-alcoholic fatty liver disease.Hepatology international · 2023Article
- Neurotensin Gene rs2234762 C>G Variant Associates with Reduced Circulating Pro-NT Levels and Predicts Lower Insulin Resistance in Overweight/Obese Children.International journal of molecular sciences · 2023Article
- Article
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
purposeTo investigate the relationship between the single-point insulin sensitivity estimator (SPISE) index, an insulin sensitivity indicator validated in adolescents and adults, and metabolic profile in overweight/obese children, and to evaluate whether basal SPISE is predictive of impaired glucose regulation (IGR) development later in life.
methodsThe SPISE index (= 600 × HDL
resultsAt baseline, 96/909 (11%) overweight/obese children had IGR; in this subgroup, SPISE was significantly lower than in normo-glycaemic youths (6.3 ± 1.7 vs. 7 ± 1.6, p < 0.001). The SPISE index correlated positively with the insulin sensitivity index (ISI) and the disposition index (DI), negatively with age, blood pressure, HOMA-IR, basal and 120 min blood glucose and insulin (all p values < 0.001). A correlation between SPISE, HOMA-IR and ISI was also reported in normal-weight children. At the 6.5-year follow-up, lower basal SPISE-but not ISI or HOMA-IR-was an independent predictor of IGR development (OR = 3.89(1.65-9.13), p = 0.002; AUROC: 0.82(0.72-0.92), p < 0.001).
conclusionIn children, low SPISE index is significantly associated with metabolic abnormalities and predicts the development of IGR in life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.