ReviewReproductive sciences (Thousand Oaks, Calif.)2022
Uterine Fibroids and Pregnancy: How Do They Affect Each Other?
Review in Reproductive sciences (Thousand Oaks, Calif.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Clinical practice guideline "preconception care".Archives of gynecology and obstetrics · 2026Guideline
- Reproductive and Obstetric Outcomes after UAE, HIFU, and TFA of Uterine Fibroids: Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2023Pooled it
- Racial disparities in uterine fibroids and endometriosis: a systematic review and application of social, structural, and political context.Fertility and sterility · 2023Pooled it
- Recovery After Transcervical Fibroid Ablation Versus Minimally Invasive Myomectomy for Symptomatic Uterine Fibroids: A Randomised Controlled Trial.BJOG : an international journal of obstetrics and gynaecology · 2026Trial
- Phthalate Metabolite, Mono(2-Ethyl-5-Hydroxyhexyl) Phthalate (MEHHP), Promotes Uterine-Fibroid-Associated Phenotypes in Myometrial Stem Cell-Derived 3D Organoids.Environmental toxicology · 2026Article
- Maternal and neonatal outcomes following cesarean myomectomy: a comparison between fibroid-associated and fibroid-free cesarean deliveries.Journal of the Turkish German Gynecological Association · 2026Article
- Reconstruction from multi-planar MRI with foundation models for uterine fibroid analysis.NPJ digital medicine · 2026Article
- Uterine fibroids detected in early pregnancy and their association with adverse pregnancy outcomes: a single-centre retrospective cohort study.BMC pregnancy and childbirth · 2026Article
- The past, present and future of uterine fibroids.Facts, views & vision in ObGyn · 2026Article
- Pregnancy complicated by a large prolapsing cervical fibroid requiring antepartum vaginal myomectomy-A case report.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Article
- Fibrosis Severity and Pro-fibrotic Gene Expression in Uterine Leiomyomas: Relationship with Self-reported Skin Color/Race and Genomic Ancestry.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Fibroids and pregnancy.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Review
- Spontaneous Rupture of Uterine Vessels Complicated with Placental Abruption: A Rare Case Report.International journal of women's health · 2026Article
- Article
- Diagnosis and classification of uterine fibroids.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Review
- Compressive force induces differential gene and protein expression in uterine fibroids.F&S science · 2025Article
- Establishment of a Predictive Model for the Efficacy of High-Intensity Focused Ultrasound in the Treatment of Uterine Fibroids.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025Article
- A Multicentric Analysis of a Pre-Ecographic Score in Pregnancy: Time for a Dedicated Classification System.Epidemiologia (Basel, Switzerland) · 2025Article
- Factors, pregnancy outcomes, and management associated with non-reportable results in prenatal cell-free DNA testing.Archives of gynecology and obstetrics · 2025Article
- Preterm placental abruption and its association with adverse maternal and neonatal outcomes: a retrospective study.BMC pregnancy and childbirth · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present narrative review is aimed to rekindle discussion regarding whether and how uterine leiomyoma and pregnancy may impact each other. Although fibroids are hormone-dependent lesions, their growth during pregnancy seems to have a nonlinear trend. Besides placental estrogens and progesterone, an array of endocrine and paracrine factors affect fibroid blood supply, growth rate, and risk of degeneration along the gestational and puerperal periods. According to current evidence, the presence of leiomyomas might increase the risk of some adverse pregnancy outcomes. Although a causative relation between fibroids and spontaneous abortion is questionable, the presence of multiple submucosal lesions in certain populations, such as infertile women, may increase the risk of pregnancy loss. Slightly increased risks of placenta previa, placental abruption and fetal malpresentation may occur, mainly due to the mechanical influence of multiple and large fibroids. Cesarean section and preterm birth rates are also probably increased in the presence of fibroids. The risk associations are based on meta-analyses of cohort studies (level of evidence 2a), retrospective cohort studies (2b), case-control (3a), and cross-sectional studies (3b), but with a predominantly low risk of bias. For evaluating the growth pattern of leiomyomas and their real influence on obstetric outcomes, future studies should enroll women with fibroids diagnosed prior to pregnancy and follow them prospectively throughout the gestation and puerperium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.